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dc.contributor.authorPuig Oriol, Xavier
dc.contributor.authorGinebra Molins, Josep
dc.contributor.authorGraffelman, Jan
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.identifier.citationPuig, X., Ginebra, J., Graffelman, J. A bayesian test for Hardy-Weinberg equilibrium of bi-allelic X-chromosomal markers. "Heredity", Juliol 2017, núm. 119, p. 226-236.
dc.description.abstractThe X chromosome is a relatively large chromosome, harboring a lot of genetic information. Much of the statistical analysis of X-chromosomal information is complicated by the fact that males only have one copy. Recently, frequentist statistical tests for Hardy–Weinberg equilibrium have been proposed specifically for dealing with markers on the X chromosome. Bayesian test procedures for Hardy–Weinberg equilibrium for the autosomes have been described, but Bayesian work on the X chromosome in this context is lacking. This paper gives the first Bayesian approach for testing Hardy–Weinberg equilibrium with biallelic markers at the X chromosome. Marginal and joint posterior distributions for the inbreeding coefficient in females and the male to female allele frequency ratio are computed, and used for statistical inference. The paper gives a detailed account of the proposed Bayesian test, and illustrates it with data from the 1000 Genomes project. In that implementation, a novel approach to tackle multiple testing from a Bayesian perspective through posterior predictive checks is used.
dc.format.extent11 p.
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica
dc.subject.lcshBayesian statistical decision theory
dc.subject.lcshX chromosome
dc.subject.otherHardy-Weinberg equilibrium
dc.subject.otherInbreeding coeffcient
dc.subject.otherBayesian model selection
dc.subject.otherPosterior distribution
dc.subject.otherDirichlet prior
dc.titleA bayesian test for Hardy-Weinberg equilibrium of bi-allelic X-chromosomal markers
dc.subject.lemacEstadística bayesiana
dc.subject.lemacGenètica -- Models estadístics
dc.contributor.groupUniversitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials
dc.contributor.groupUniversitat Politècnica de Catalunya. COSDA-UPC - COmpositional and Spatial Data Analysis
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
local.citation.authorPuig, X.; Ginebra, J.; Graffelman, J.

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