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A “HOLTER” for Parkinson's disease: validation of the ability to detect on-off states using the REMPARK system

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10.1016/j.gaitpost.2017.09.031
 
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Bayés, Àngels
Samà Monsonís, AlbertMés informacióMés informació
Prats París, Anna
Pérez López, CarlosMés informació
Moreno Aróstegui, Juan ManuelMés informacióMés informacióMés informació
Rodríguez Martín, Daniel ManuelMés informacióMés informació
Cabestany Moncusí, JoanMés informacióMés informacióMés informació
Document typeArticle
Defense date2018-01-01
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
The treatment of Parkinson's disease (PD) with levodopa is very effective. However, over time, motor complications (MCs) appear, restricting the patient from leading a normal life. One of the most disabling MCs is ON-OFF fluctuations. Gathering accurate information about the clinical status of the patient is essential for planning treatment and assessing its effect. Systems such as the REMPARK system, capable of accurately and reliably monitoring ON-OFF fluctuations, are of great interest. Objective To analyze the ability of the REMPARK System to detect ON-OFF fluctuations. Methods Forty-one patients with moderate to severe idiopathic PD were recruited according to the UK Parkinson's Disease Society Brain Bank criteria. Patients with motor fluctuations, freezing of gait and/or dyskinesia and who were able to walk unassisted in the OFF phase, were included in the study. Patients wore the REMPARK System for 3 days and completed a diary of their motor state once every hour. Results The record obtained by the REMPARK System, compared with patient-completed diaries, demonstrated 97% sensitivity in detecting OFF states and 88% specificity (i.e., accuracy in detecting ON states). Conclusion The REMPARK System detects an accurate evaluation of ON-OFF fluctuations in PD; this technology paves the way for an optimisation of the symptomatic control of PD motor symptoms as well as an accurate assessment of medication efficacy.
CitationBayés, À., Sama, A., Prats, A., Perez, C., Moreno, J., Rodriguez-Martin, D., Cabestany, J. A “HOLTER” for Parkinson's disease: validation of the ability to detect on-off states using the REMPARK system. "Gait and posture", 1 Gener 2018, vol. 59, p. 1-6. 
URIhttp://hdl.handle.net/2117/110568
DOI10.1016/j.gaitpost.2017.09.031
ISSN0966-6362
Publisher versionhttp://www.gaitposture.com/article/S0966-6362(17)30936-0/fulltext
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  • CETpD -Centre d'Estudis Tecnològics per a l'Atenció a la Dependència i la Vida Autònoma - Articles de revista [31]
  • Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial - Articles de revista [1.535]
  • Departament d'Enginyeria Electrònica - Articles de revista [1.860]
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