Design and fabrication of functionalized high porous poly(lactic acid)-based scaffolds for tissue engineering

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Chair / Department / Institute
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
Document typeDoctoral thesis
Data de defensa2016-01-26
PublisherUniversitat Politècnica de Catalunya
Rights accessOpen Access
Abstract
Intelligent scaffolds are designed to trigger the healing regeneration process through the controlled released or disposition of bioactive signals. The fabrication of intelligent scaffolds needs the development of novel techniques able to introduce biomimetic properties on the final product through easy and scalable techniques. This thesis is focused on the characterization and development of two versatile techniques for the fabrication of intelligent scaffolds. The first technique is based on the biofunctionalization of polymeric surfaces with synthetic polypeptides (elastin-like recombinamers) for the improvement of cell-surface interactions. The second technique is based on the fabrication of highly porous poly(lactic) acid scaffolds with a nano-fibrous structure that resembles the natural extracellular matrix by means of a novel non-toxic, cheap and easy process. Los andamios inteligentes son diseñados para activar los procesos de regeneración a través de la dosificación o disposición controlada de señales bioactivas. Sin embargo es necesario desarrollar nuevas técnicas capaces de introducir propiedades biomemiméticas en dichos andamios a través de metodologías sencillas e industrializables. La presente tesis se centra en la caracterización y desarrollo de dos técnicas versátiles para la fabricación de andamios inteligentes. La primera técnica se basa en la biofuncionalización de superficies poliméricas con polipéptidos sintéticos (elastin-like recombinamers) para la mejora de las interacciones entre las células y la superficie del material. La segunda técnica se basa en la fabricación de andamios de ácido poli(láctico) altamente porosos, con una estructura nano-fibrosa que mimetiza la matriz extracelular, a través de procesos fáciles, económicos y no tóxicos.
CitationPuñet Ortiz, X. Design and fabrication of functionalized high porous poly(lactic acid)-based scaffolds for tissue engineering. Tesi doctoral, UPC, Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, 2016. Available at: <http://hdl.handle.net/2117/109816>
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