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dc.contributorEchebarría Domínguez, Blas
dc.contributorPeñaranda Ayllón, Angelina
dc.contributor.authorKrizanec, Nikolina
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2017-10-25T10:22:53Z
dc.date.available2017-10-25T10:22:53Z
dc.date.issued2017-10
dc.identifier.urihttp://hdl.handle.net/2117/109143
dc.description.abstractThe aim of this master s thesis is to study the basic cardiac cellular electrophysiology in order to understand and examine the role of SK3 channels. Among the many channels present in an atrial myocyte, SK3 channels are activated by calcium, providing the circulation of the intracellular calcium. A well established mathematical model, the Grandi model, forms the basis of the simulations presented in this project. First, to study the effect of the SK current, a modification of the atrial myocyte model is done. Secondly, the model is calibrated according to experimental results. Lastly, we study the effect of the SK currents to avoid spontaneous calcium release induced depolarizations. Numerical simulations of the whole-cell atrial myocyte performed in this project confirmed the anti arrhythmic behaviour of the SK current, that counteracts the effect of spontaneous calcium release. This effect is, however, not large and, therefore, does not seem to support the, development of SK channel blockers as a new therapeutic strategy in the treatment of atrial fibrillation, as has been suggested in the literature.
dc.language.isoeng
dc.publisherUniversitat Politècnica de Catalunya
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subject.lcshBiology
dc.subject.lcshNatural history
dc.subject.otherCardiac electrophysiology
dc.subject.otherSK channels
dc.subject.otherAtrial fibrillation
dc.titleMathematical modeling of calcium handling dysfunctions leading to atrial fibrillation
dc.typeMaster thesis
dc.subject.lemacBiologia
dc.subject.lemacCiències naturals
dc.subject.amsClassificació AMS::92 Biology and other natural sciences
dc.identifier.slugFME-1249
dc.rights.accessOpen Access
dc.date.updated2017-10-19T05:23:45Z
dc.audience.educationlevelMàster
dc.audience.mediatorUniversitat Politècnica de Catalunya. Facultat de Matemàtiques i Estadística
dc.audience.degreeMÀSTER UNIVERSITARI EN MATEMÀTICA AVANÇADA I ENGINYERIA MATEMÀTICA (Pla 2010)


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