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dc.contributor.authorPuiggalí Jou, Anna
dc.contributor.authorMicheletti, Paolo
dc.contributor.authorEstrany Coda, Francesc
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.authorAlemán Llansó, Carlos
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2017-10-11T06:26:51Z
dc.date.available2017-10-11T06:26:51Z
dc.date.issued2017-09-20
dc.identifier.citationPuiggali, A., Micheletti, P., Estrany, F., del Valle, LJ., Aleman, C. Electrostimulated release of neutral drugs from polythiophene nanoparticles: smart regulation of drug-polymer interactions. "Advanced healthcare materials", 20 Setembre 2017, vol. 6, núm. 18, p. 1-11.
dc.identifier.issn2192-2640
dc.identifier.urihttp://hdl.handle.net/2117/108627
dc.description.abstractPoly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles are loaded with curcumin and piperine by in situ emulsion polymerization using dodecyl benzene sulfonic acid both as a stabilizer and a doping agent. The loaded drugs affect the morphology, size, and colloidal stability of the nanoparticles. Furthermore, kinetics studies of nonstimulated drug release have evidenced that polymer···drug interactions are stronger for curcumin than for piperine. This observation suggests that drug delivery systems based on combination of the former drug with PEDOT are much appropriated to show an externally tailored release profile. This is demonstrated by comparing the release profiles obtained in presence and absence of electrical stimulus. Results indicate that controlled and time-programmed release of curcumin is achieved in a physiological medium by applying a negative voltage of -1.25 V to loaded PEDOT nanoparticles.
dc.format.extent11 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshNanocomposites (Materials)
dc.subject.lcshBiochemical engineering
dc.subject.lcshBiopolymers
dc.subject.otheranticancer agents
dc.subject.otherconducting polymers
dc.subject.othercontrolled release
dc.subject.othercurcumine
dc.subject.otherpiperine
dc.titleElectrostimulated release of neutral drugs from polythiophene nanoparticles: smart regulation of drug-polymer interactions
dc.typeArticle
dc.subject.lemacNanocompòsits (Materials)
dc.subject.lemacEnginyeria biomèdica
dc.subject.lemacBiopolímers
dc.subject.lemacPolímers conductors
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM - Innovació, Modelització i Enginyeria en (BIO) Materials
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables
dc.identifier.doi10.1002/adhm.201700453
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/adhm.201700453/abstract;jsessionid=B0A6E6C6727BBF9F10BDC6A11BDE1285.f04t02
dc.rights.accessOpen Access
local.identifier.drac21564139
dc.description.versionPostprint (author's final draft)
local.citation.authorPuiggali, A.; Micheletti, P.; Estrany, F.; del Valle, LJ.; Aleman, C.
local.citation.publicationNameAdvanced healthcare materials
local.citation.volume6
local.citation.number18
local.citation.startingPage1
local.citation.endingPage11


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