Mostra el registre d'ítem simple
Electrostimulated release of neutral drugs from polythiophene nanoparticles: smart regulation of drug-polymer interactions
dc.contributor.author | Puiggalí Jou, Anna |
dc.contributor.author | Micheletti, Paolo |
dc.contributor.author | Estrany Coda, Francesc |
dc.contributor.author | Valle Mendoza, Luis Javier del |
dc.contributor.author | Alemán Llansó, Carlos |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2017-10-11T06:26:51Z |
dc.date.available | 2017-10-11T06:26:51Z |
dc.date.issued | 2017-09-20 |
dc.identifier.citation | Puiggali, A., Micheletti, P., Estrany, F., del Valle, LJ., Aleman, C. Electrostimulated release of neutral drugs from polythiophene nanoparticles: smart regulation of drug-polymer interactions. "Advanced healthcare materials", 20 Setembre 2017, vol. 6, núm. 18, p. 1-11. |
dc.identifier.issn | 2192-2640 |
dc.identifier.uri | http://hdl.handle.net/2117/108627 |
dc.description.abstract | Poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles are loaded with curcumin and piperine by in situ emulsion polymerization using dodecyl benzene sulfonic acid both as a stabilizer and a doping agent. The loaded drugs affect the morphology, size, and colloidal stability of the nanoparticles. Furthermore, kinetics studies of nonstimulated drug release have evidenced that polymer···drug interactions are stronger for curcumin than for piperine. This observation suggests that drug delivery systems based on combination of the former drug with PEDOT are much appropriated to show an externally tailored release profile. This is demonstrated by comparing the release profiles obtained in presence and absence of electrical stimulus. Results indicate that controlled and time-programmed release of curcumin is achieved in a physiological medium by applying a negative voltage of -1.25 V to loaded PEDOT nanoparticles. |
dc.format.extent | 11 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Nanocomposites (Materials) |
dc.subject.lcsh | Biochemical engineering |
dc.subject.lcsh | Biopolymers |
dc.subject.other | anticancer agents |
dc.subject.other | conducting polymers |
dc.subject.other | controlled release |
dc.subject.other | curcumine |
dc.subject.other | piperine |
dc.title | Electrostimulated release of neutral drugs from polythiophene nanoparticles: smart regulation of drug-polymer interactions |
dc.type | Article |
dc.subject.lemac | Nanocompòsits (Materials) |
dc.subject.lemac | Enginyeria biomèdica |
dc.subject.lemac | Biopolímers |
dc.subject.lemac | Polímers conductors |
dc.contributor.group | Universitat Politècnica de Catalunya. IMEM - Innovació, Modelització i Enginyeria en (BIO) Materials |
dc.contributor.group | Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
dc.identifier.doi | 10.1002/adhm.201700453 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/adhm.201700453/abstract;jsessionid=B0A6E6C6727BBF9F10BDC6A11BDE1285.f04t02 |
dc.rights.access | Open Access |
local.identifier.drac | 21564139 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Puiggali, A.; Micheletti, P.; Estrany, F.; del Valle, LJ.; Aleman, C. |
local.citation.publicationName | Advanced healthcare materials |
local.citation.volume | 6 |
local.citation.number | 18 |
local.citation.startingPage | 1 |
local.citation.endingPage | 11 |
Fitxers d'aquest items
Aquest ítem apareix a les col·leccions següents
-
Articles de revista [398]
-
Articles de revista [181]
-
Articles de revista [2.214]