Ir al contenido (pulsa Retorno)

Universitat Politècnica de Catalunya

    • Català
    • Castellano
    • English
    • LoginRegisterLog in (no UPC users)
  • mailContact Us
  • world English 
    • Català
    • Castellano
    • English
  • userLogin   
      LoginRegisterLog in (no UPC users)

UPCommons. Global access to UPC knowledge

Banner header
61.603 UPC E-Prints
You are here:
View Item 
  •   DSpace Home
  • E-prints
  • Grups de recerca
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
  • Articles de revista
  • View Item
  •   DSpace Home
  • E-prints
  • Grups de recerca
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
  • Articles de revista
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Electrostimulated release of neutral drugs from polythiophene nanoparticles: smart regulation of drug-polymer interactions

Thumbnail
View/Open
Puiggali-Jou_etal_rev.pdf (1,429Mb)
 
10.1002/adhm.201700453
 
  View Usage Statistics
  LA Referencia / Recolecta stats
Cita com:
hdl:2117/108627

Show full item record
Puiggalí Jou, AnnaMés informacióMés informació
Micheletti, Paolo
Estrany Coda, FrancescMés informacióMés informacióMés informació
Valle Mendoza, Luis Javier delMés informacióMés informacióMés informació
Alemán Llansó, CarlosMés informacióMés informacióMés informació
Document typeArticle
Defense date2017-09-20
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles are loaded with curcumin and piperine by in situ emulsion polymerization using dodecyl benzene sulfonic acid both as a stabilizer and a doping agent. The loaded drugs affect the morphology, size, and colloidal stability of the nanoparticles. Furthermore, kinetics studies of nonstimulated drug release have evidenced that polymer···drug interactions are stronger for curcumin than for piperine. This observation suggests that drug delivery systems based on combination of the former drug with PEDOT are much appropriated to show an externally tailored release profile. This is demonstrated by comparing the release profiles obtained in presence and absence of electrical stimulus. Results indicate that controlled and time-programmed release of curcumin is achieved in a physiological medium by applying a negative voltage of -1.25 V to loaded PEDOT nanoparticles.
CitationPuiggali, A., Micheletti, P., Estrany, F., del Valle, LJ., Aleman, C. Electrostimulated release of neutral drugs from polythiophene nanoparticles: smart regulation of drug-polymer interactions. "Advanced healthcare materials", 20 Setembre 2017, vol. 6, núm. 18, p. 1-11. 
URIhttp://hdl.handle.net/2117/108627
DOI10.1002/adhm.201700453
ISSN2192-2640
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/adhm.201700453/abstract;jsessionid=B0A6E6C6727BBF9F10BDC6A11BDE1285.f04t02
Collections
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies - Articles de revista [385]
  • PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables. - Articles de revista [181]
  • Departament d'Enginyeria Química - Articles de revista [2.116]
  View Usage Statistics

Show full item record

FilesDescriptionSizeFormatView
Puiggali-Jou_etal_rev.pdf1,429MbPDFView/Open

Browse

This CollectionBy Issue DateAuthorsOther contributionsTitlesSubjectsThis repositoryCommunities & CollectionsBy Issue DateAuthorsOther contributionsTitlesSubjects

© UPC Obrir en finestra nova . Servei de Biblioteques, Publicacions i Arxius

info.biblioteques@upc.edu

  • About This Repository
  • Contact Us
  • Send Feedback
  • Privacy Settings
  • Inici de la pàgina