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dc.contributor.authorHoyos Nogués, Mireia
dc.contributor.authorVelasco, Ferran
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.authorManero Planella, José María
dc.contributor.authorGil Mur, Francisco Javier
dc.contributor.authorMas Moruno, Carlos
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2017-07-24T09:47:02Z
dc.date.issued2017-07-05
dc.identifier.citationHoyos, M., Velasco, F., Ginebra, M.P., Manero, J., Gil, J., Mas-Moruno, C. Regenerating bone via multifunctional coatings: the blending of cell integration and bacterial inhibition properties on the surface of biomaterials. "ACS applied materials and interfaces", 5 Juliol 2017, vol. 9, núm. 26, p. 21618-21630.
dc.identifier.issn1944-8244
dc.identifier.urihttp://hdl.handle.net/2117/106732
dc.description.abstractIn dentistry and orthopedics, it is well accepted that implant fixation is a major goal. However, an emerging concern is bacterial infection. Infection of metallic implants can be catastrophic and significantly reduce patient quality of life. Accordingly, in this work, we focus on multifunctional coatings to simultaneously address and mitigate both these problems. We have developed a tailor-made peptide-based chemical platform that integrates the well-known RGD cell adhesive sequence and the lactoferrin-derived LF1-11 antimicrobial peptide. The platform was covalently grafted on titanium via silanization and the functionalization process characterized by contact angle, XPS, and QCM-D. The presence of the platform statistically improved the adhesion, proliferation and mineralization of osteoblast-like cells compared to control surfaces. At the same time, colonization by representative bacterial strains was significantly reduced on the surfaces. Furthermore, the biological potency of the multifunctional platform was verified in a co-culture in vitro model. Our findings demonstrate that this multifunctional approach can be useful to functionalize biomaterials to both improve cell integration and reduce the risk of bacterial infection.
dc.format.extent13 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshPeptide antibiotics
dc.subject.lcshOsseointegration
dc.subject.othermultifunctionality
dc.subject.otherantimicrobial peptides
dc.subject.othercell adhesive peptides
dc.subject.otherosseointegration
dc.subject.othersurface functionalization
dc.titleRegenerating bone via multifunctional coatings: the blending of cell integration and bacterial inhibition properties on the surface of biomaterials
dc.typeArticle
dc.subject.lemacPèptids
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1021/acsami.7b03127
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://pubs.acs.org/doi/abs/10.1021/acsami.7b03127
dc.rights.accessRestricted access - publisher's policy
drac.iddocument21204591
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
upcommons.citation.authorHoyos, M.; Velasco, F.; Ginebra, M.P.; Manero, J.; Gil, J.; Mas-Moruno, C.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameACS applied materials and interfaces
upcommons.citation.volume9
upcommons.citation.number26
upcommons.citation.startingPage21618
upcommons.citation.endingPage21630


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