Experimental and topological determination of the pressure-temperature phase diagram of morniflumate, a pharmaceutical ingredient with anti-inflammatory properties
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The pressure-temperature phase diagram of morniflumate (niflumic acid ß-morpholinoethyl ester) has been obtained by high-pressure thermal analysis. In addition, calorimetric melting data (TI¿L = (348.1 ± 0.4) K and ¿HI¿L = (89 ± 2) J·g-1) and the specific volumes of the solid and the liquid state have been obtained under normal pressure. Comparison of the measured high-pressure melting data with the equilibrium curve obtained through the Clapeyron equation indicates that the initial slopes are the same (dP/dT = (2.96 ± 0.06) MPa·K-1) at the melting point under normal pressure. The fact that the Clapeyron equation can be used to construct topological phase diagrams may be of interest for the food and pharmaceutical industries.
CitationDel Barrio, M., Tamarit, J. Ll., Céolin, R., Robert, B., Guechot, C., Teulon, J., Rietveld, I. Experimental and topological determination of the pressure-temperature phase diagram of morniflumate, a pharmaceutical ingredient with anti-inflammatory properties. "Journal of chemical thermodynamics", 1 Setembre 2017, vol. 112, p. 308-313.