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dc.contributor.authorGilabert Chirivella, Eduardo
dc.contributor.authorPérez Feito, Ricardo
dc.contributor.authorRibeiro, Clarisse
dc.contributor.authorRibeiro, Sylvie
dc.contributor.authorCorreia, Daniela
dc.contributor.authorGonzález Martin, María Luisa
dc.contributor.authorManero Planella, José María
dc.contributor.authorLanceros Méndez, Senentxu
dc.contributor.authorGallego Ferrer, Gloria
dc.contributor.authorGómez Ribelles, José Luis
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.identifier.citationGilabert, E., Pérez, R., Ribeiro, C., Ribeiro, S., Correia, D., González, M., Manero, J., Lanceros-Mendez, S., Gallego, G., Gómez , J. Chitosan patterning on titanium alloys. "Progress in organic coatings", 2017, vol. 111, p. 23-28.
dc.description.abstractTitanium and its alloys are widely used in medical implants because of their excellent properties. However, bacterial infection is a frequent cause of titanium-based implant failure and also compromises its osseointegration. In this study, we report a new simple method of providing titanium surfaces with antibacterial properties by alternating antibacterial chitosan domains with titanium domains in the micrometric scale. Surface microgrooves were etched on pure titanium disks at intervals of 60 μm using a modified 3D printer and were then coated with chitosan antibacterial polysaccharide. The dimensions of the patterned microgrooves made it possible to fix the chitosan domains to the titanium substrate without the need for covalent bonding. These domains were stable after 5 days of immersion in water and reduced the surface contact angle. Preliminary cell adhesion assays demonstrated that MC3T3-E1 pre-osteoblasts preferentially adhered to the titanium regions, while C2C12 myoblasts were uniformly distributed over the whole surface.
dc.format.extent6 p.
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshCell adhesion
dc.titleChitosan patterning on titanium alloys
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
dc.contributor.covenanteeUniversitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular
local.citation.authorGilabert, E.; Pérez, R.; Ribeiro, C.; Ribeiro, S.; Correia, D.; González, M.; Manero, J.; Lanceros-Mendez, S.; Gallego, G.; Gómez, J.
local.citation.publicationNameProgress in organic coatings

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