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Prospective study to assess progression of renal markers after interruption of tenofovir due to nephrotoxicity
dc.contributor.author | Bonjoch Badia, Anna |
dc.contributor.author | Echeverria Liras, Patricia |
dc.contributor.author | Pérez Álvarez, Nuria |
dc.contributor.author | Puig, Jordi |
dc.contributor.author | Estany Quera, Carla |
dc.contributor.author | Clotet Sala, Bonaventura |
dc.contributor.author | Negredo Puigmal, Eugènia |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa |
dc.date.accessioned | 2017-06-12T12:14:32Z |
dc.date.available | 2017-06-12T12:14:32Z |
dc.date.issued | 2016 |
dc.identifier.citation | Bonjoch, A., Echeverria, P., Perez, N., Puig, J., Estany, C., Clotet, B., Negredo, E. Prospective study to assess progression of renal markers after interruption of tenofovir due to nephrotoxicity. "Biomed Research International", 2016. |
dc.identifier.issn | 2314-6133 |
dc.identifier.uri | http://hdl.handle.net/2117/105352 |
dc.description.abstract | Background. Prospective studies about the reversibility of tenofovir disoproxil fumarate- (TDF-) related renal impairment remain scarce. Methods. This is an observational prospective study including all patients that presented at our HIV Unit who interrupted TDF owing to nephrotoxicity. We assessed the evolution of renal parameters after discontinuation of this drug. Results. We included 59 patients, who were followed up for 72 weeks. Most were male (41, 69.5%), median (IQR) age was 53 (44; 58) years, and median time receiving TDF-containing regimens was 55.4 (28; 87.7) months. Most patients were receiving PI-based treatments (67%). At the final visit, most of the subjects showed complete recovery (35, 59.3%) or improvement (13 subjects, 22%). Significant improvements were observed in creatinine levels (from 84.9 [73.8; 97.5] to 78 [69.6; 91] mu mol/L, p = 0.013), estimated glomerular filtration rate (eGFR, CKD EPI equation, from 87.7 [67; 99] to 89.9 [73.6; 99.3] mL/min/1.73 m(2), p = 0.017), and number of patients with eGFR <60 mL/min/1.73 m(2) (from 9 [15.3%] to 1 [1.7%], p = 0.031). A trend toward significance was observed in abnormal urine proteinuria/creatinine ratio (from 22 [37%] to 8 [13.6%], p = 0.057). Conclusions. Our results corroborate the high frequency of complete or partial renal recovery in patients receiving TDF-containing regimens who discontinued therapy owing to nephrotoxicity. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Investigació operativa |
dc.title | Prospective study to assess progression of renal markers after interruption of tenofovir due to nephrotoxicity |
dc.type | Article |
dc.contributor.group | Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica |
dc.identifier.doi | 10.1155/2016/4380845 |
dc.description.peerreviewed | Peer Reviewed |
dc.subject.ams | Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics |
dc.relation.publisherversion | https://www.hindawi.com/journals/bmri/2016/4380845/ |
dc.rights.access | Open Access |
local.identifier.drac | 19812497 |
dc.description.version | Postprint (published version) |
local.citation.author | Bonjoch, A.; Echeverria, P.; Perez, N.; Puig, J.; Estany, C.; Clotet, B.; Negredo, E. |
local.citation.publicationName | Biomed Research International |
dc.identifier.pmid | 28078289 |
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