Show simple item record

dc.contributor.authorGilabert Chirivella, Eduardo
dc.contributor.authorPerez Feito, Ricardo
dc.contributor.authorRibeiro, Clarisse
dc.contributor.authorRibeiro, Sylvie
dc.contributor.authorCorreia, Daniela M.
dc.contributor.authorGonzalez Martin, Maria Luisa
dc.contributor.authorManero Planella, José María
dc.contributor.authorLanceros Méndez, Senentxu
dc.contributor.authorGallego Ferrer, Gloria
dc.contributor.authorGómez Ribelles, José Luis
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2017-06-09T11:13:48Z
dc.date.available2017-06-09T11:13:48Z
dc.date.issued2017-10-01
dc.identifier.citationGilabert Chirivella, E., Perez, R., Ribeiro, C., Ribeiro, S., Correia, D., Gonzalez, M., Manero, J., Lanceros-Mendez, S., Gallego, G., Gómez, J. Chitosan patterning on titanium implants. "Progress in organic coatings", 1 Octubre 2017, vol. 111, p. 23-28.
dc.identifier.issn0300-9440
dc.identifier.urihttp://hdl.handle.net/2117/105280
dc.description.abstractTitanium and its alloys are widely used in medical implants because of their excellent properties. However, bacterial infection is a frequent cause of titanium-based implant failure and also compromises its osseointegration. In this study, we report a new simple method of providing titanium surfaces with antibacterial properties by alternating antibacterial chitosan domains with titanium domains in the micrometric scale. Surface microgrooves were etched on pure titanium disks at intervals of 60 µm using a modified 3D printer and were then coated with chitosan antibacterial polysaccharide. The dimensions of the patterned microgrooves made it possible to fix the chitosan domains to the titanium substrate without the need for covalent bonding. These domains were stable after 5 days of immersion in water and reduced the surface contact angle. Preliminary cell adhesion assays demonstrated that MC3T3-E1 pre-osteoblasts preferentially adhered to the titanium regions, while C2C12 myoblasts were uniformly distributed over the whole surface.
dc.format.extent6 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshTitanium
dc.subject.lcshChitosan
dc.subject.lcshMyoblasts
dc.subject.lcshCell adhesion
dc.subject.otherTitanium
dc.subject.otherMicrogrooves
dc.subject.otherChitosan
dc.subject.otherMyoblasts
dc.subject.otherPre-osteoblasts
dc.subject.otherCell adhesion
dc.titleChitosan patterning on titanium implants
dc.typeArticle
dc.subject.lemacTitani
dc.subject.lemacQuitosan
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.porgcoat.2017.04.027
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0300944016304258
dc.rights.accessOpen Access
local.identifier.drac21076203
dc.description.versionPostprint (author's final draft)
dc.contributor.covenanteeUniversitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular
local.citation.authorGilabert Chirivella, E.; Perez, R.; Ribeiro, C.; Ribeiro, S.; Correia, D.; Gonzalez, M.; Manero, J.; Lanceros-Mendez, S.; Gallego, G.; Gómez, J.
local.citation.publicationNameProgress in organic coatings
local.citation.volume111
local.citation.startingPage23
local.citation.endingPage28


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

All rights reserved. This work is protected by the corresponding intellectual and industrial property rights. Without prejudice to any existing legal exemptions, reproduction, distribution, public communication or transformation of this work are prohibited without permission of the copyright holder