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dc.contributor.authorLópez Vilanova, Natalia
dc.contributor.authorPavia, J.
dc.contributor.authorDuch Guillen, María Amor
dc.contributor.authorCatafau, A.
dc.contributor.authorRos, D.
dc.contributor.authorBullich, S.
dc.contributor.otherUniversitat Politècnica de Catalunya. Institut de Tècniques Energètiques
dc.date.accessioned2017-05-31T11:08:48Z
dc.date.available2018-04-03T00:30:33Z
dc.date.issued2017-04-01
dc.identifier.citationLopez, N., Pavia, J., Duch, M., Catafau, A., Ros, D., Bullich, S. Impact of region-of-interest delineation methods, reconstruction algorithms, and intra- and inter-operator variability on internal dosimetry estimates using PET. "Molecular imaging and biology", 1 Abril 2017, vol. 19, núm. 2, p. 305-314.
dc.identifier.issn1536-1632
dc.identifier.urihttp://hdl.handle.net/2117/105067
dc.description.abstractPurpose Human dosimetry studies play a central role in radioligand development for positron emission tomography (PET). Drawing regions of interest (ROIs) on the PET images is used to measure the dose in each organ. In the study aspects related to ROI delineation methods were evaluated for two radioligands of different biodistribution (intestinal vs urinary). Procedures PET images were simulated from a human voxel-based phantom. Several ROI delineation methods were tested: antero-posterior projections (AP), 3D sub-samples of the organs (S), and a 3D volume covering the whole-organ (W). Inter- and intra-operator variability ROI drawing was evaluated by using human data. Results The effective dose estimates using S and W methods were comparable to the true values. AP methods overestimated (49 %) the dose for the radioligand with intestinal biodistribution. Moreover, the AP method showed the highest inter-operator variability: 11 ± 1 %. Conclusions The sub-sampled organ method showed the best balance between quantitative accuracy and inter- and intra-operator variability.
dc.format.extent10 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física::Electromagnetisme
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Diagnòstic per la imatge
dc.subject.lcshRadiation dosimetry
dc.subject.otherPET
dc.subject.otherDosimetry
dc.subject.other[C-11]raclopride
dc.subject.other[C-11]GSK931145
dc.titleImpact of region-of-interest delineation methods, reconstruction algorithms, and intra- and inter-operator variability on internal dosimetry estimates using PET
dc.typeArticle
dc.subject.lemacRadiació--Dosimetria
dc.contributor.groupUniversitat Politècnica de Catalunya. DRM - Dosimetria i Radiofísica Mèdica
dc.identifier.doi10.1007/s11307-016-1003-4
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs11307-016-1003-4
dc.rights.accessOpen Access
local.identifier.drac20329912
dc.description.versionPostprint (author's final draft)
local.citation.authorLopez, N.; Pavia, J.; Duch, M.; Catafau, A.; Ros, D.; Bullich, S.
local.citation.publicationNameMolecular imaging and biology
local.citation.volume19
local.citation.number2
local.citation.startingPage305
local.citation.endingPage314


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