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Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide
dc.contributor.author | Barrio Casado, María del |
dc.contributor.author | Huguet, Jordi |
dc.contributor.author | Robert, B. |
dc.contributor.author | Rietveld, Ivo B. |
dc.contributor.author | Céolin, René |
dc.contributor.author | Tamarit Mur, José Luis |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física |
dc.date.accessioned | 2017-05-19T14:13:29Z |
dc.date.available | 2017-05-19T14:13:29Z |
dc.date.issued | 2017-06-15 |
dc.identifier.citation | Del Barrio, M., Huguet, J., Robert, B., Rietveld, I., Céolin, R., Tamarit, J. L. Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide. "International journal of pharmaceutics", 15 Juny 2017, vol. 525, núm. 1, p. 54-59. |
dc.identifier.issn | 0378-5173 |
dc.identifier.uri | http://hdl.handle.net/2117/104659 |
dc.description.abstract | Understanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however up to now its stability behavior was not clear, as few thermodynamic data were available. Therefore, calorimetric melting data have been obtained, which were found to be TI-L = 422.4 ± 1.0 K, ¿I ¿ LH = 117.5 ± 5.2 J g-1, TII-L = 419.8 ± 1.0 K and ¿II ¿ LH = 108.6 ± 3.3 J g-1. In addition, vapor-pressure data, high-pressure melting data, and specific volumes have been obtained. It is demonstrated that form II is intrinsically monotropic in relation to form I and the latter would thus be the best polymorph to use for drug formulations. This result has been obtained by experimental means, involving high-pressure measurements. Furthermore, it has been shown that with very limited experimental and statistical data, the same conclusion can be obtained, demonstrating that in first instance topological pressure-temperature phase diagrams can be obtained without necessarily measuring any high-pressure data. It provides a quick method to verify the phase behavior of the known phases of an active pharmaceutical ingredient under different pressure and temperature conditions. |
dc.format.extent | 6 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Física |
dc.subject.lcsh | Calorimetry |
dc.subject.lcsh | Crystallography |
dc.subject.lcsh | Polymorphism (Crystallography) |
dc.subject.lcsh | Thermodynamics |
dc.subject.other | Polymorphism |
dc.subject.other | Thermodynamics |
dc.subject.other | Pressure-temperature phase diagram |
dc.subject.other | Phase behavior |
dc.subject.other | Crystallography |
dc.subject.other | Calorimetry |
dc.subject.other | Preformulation |
dc.title | Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide |
dc.type | Article |
dc.subject.lemac | Termodinàmica |
dc.subject.lemac | Cristal·lografia |
dc.subject.lemac | Calorimetria |
dc.subject.lemac | Polimorfisme (Cristal·lografia) |
dc.contributor.group | Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials |
dc.identifier.doi | 10.1016/j.ijpharm.2017.04.016 |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0378517317302971 |
dc.rights.access | Open Access |
local.identifier.drac | 20335644 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Del Barrio, M.; Huguet, J.; Robert, B.; Rietveld, I.; Céolin, R.; Tamarit, J. Ll. |
local.citation.publicationName | International journal of pharmaceutics |
local.citation.volume | 525 |
local.citation.number | 1 |
local.citation.startingPage | 54 |
local.citation.endingPage | 59 |
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