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dc.contributor.authorCapasso, Serena
dc.contributor.authorSticco, Lucia
dc.contributor.authorRizzo, Riccardo
dc.contributor.authorPirozzi, Marinella
dc.contributor.authorRusso, Domenico
dc.contributor.authorDathan, Nina A.
dc.contributor.authorCampelo, Felix
dc.contributor.authorGalen, Josse van
dc.contributor.authorHölttä-Vuori, Maarit
dc.contributor.authorTuracchio, Gabriele
dc.contributor.authorHausser, Angelika
dc.contributor.authorMalhotra, Vivek
dc.contributor.authorRiezman, Isabelle
dc.contributor.authorRiezman, Howard
dc.contributor.authorIkonen, Elina
dc.contributor.authorLuberto, Chiara
dc.contributor.authorParashuraman, Seetharaman
dc.contributor.authorLuini, Alberto
dc.contributor.authorAngelo, Giovanni D
dc.contributor.otherUniversitat Politècnica de Catalunya. Institut de Ciències Fotòniques
dc.date.accessioned2017-05-16T11:01:33Z
dc.date.available2017-10-10T00:30:37Z
dc.date.issued2017-04-10
dc.identifier.citationCapasso, S. [et al.]. Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network. "EMBO Journal", 10 Abril 2017.
dc.identifier.issn0261-4189
dc.identifier.urihttp://hdl.handle.net/2117/104499
dc.description.abstractSphingolipids are membrane lipids, which are globally required for eukaryotic life. Sphingolipid composition varies among endomembranes with pre- and post-Golgi compartments being poor and rich in sphingolipids, respectively. Thanks to this different sphingolipid content, pre- and post-Golgi membranes serve different cellular functions. Nevertheless, how subcellular sphingolipid levels are maintained in spite of trafficking and metabolic fluxes is only partially understood. Here we describe a homeostatic control circuit that controls sphingolipid levels at the trans Golgi network. Specifically, we show that sphingomyelin production at the trans Golgi network triggers a signalling reaction leading to PtdIns(4)P dephosphorylation. Since PtdIns(4)P is required for cholesterol, and sphingolipid transport to the trans Golgi network, PtdIns(4)P consumption leads to the interruption of this transport in response to excessive sphingomyelin production. Based on this evidence we envisage a model where this homeostatic circuit maintains the lipid composition of trans Golgi network and thus of post-Golgi compartments constant, against instant fluctuations in the sphingolipid biosynthetic flow.
dc.format.extent50 p.
dc.language.isoeng
dc.publisherEmbo press
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshMetabolism
dc.subject.otherGolgi network
dc.titleSphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network
dc.typeArticle
dc.subject.lemacMetabolisme
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://emboj.embopress.org/content/early/2017/05/10/embj.201696048
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
dc.relation.projectidGR-2011-02352256
upcommons.citation.publishedtrue
upcommons.citation.publicationNameEMBO Journal


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