Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network
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Tipus de documentArticle
Data publicació2017-04-10
EditorEmbo press
Condicions d'accésAccés obert
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Sphingolipids are membrane lipids, which are globally required for eukaryotic life.
Sphingolipid composition varies among endomembranes with pre- and post-Golgi
compartments being poor and rich in sphingolipids, respectively. Thanks to this different
sphingolipid content, pre- and post-Golgi membranes serve different cellular functions.
Nevertheless, how subcellular sphingolipid levels are maintained in spite of trafficking and
metabolic fluxes is only partially understood. Here we describe a homeostatic control
circuit that controls sphingolipid levels at the trans Golgi network. Specifically, we show
that sphingomyelin production at the trans Golgi network triggers a signalling reaction
leading to PtdIns(4)P dephosphorylation. Since PtdIns(4)P is required for cholesterol, and
sphingolipid transport to the trans Golgi network, PtdIns(4)P consumption leads to the
interruption of this transport in response to excessive sphingomyelin production. Based on
this evidence we envisage a model where this homeostatic circuit maintains the lipid
composition of trans Golgi network and thus of post-Golgi compartments constant, against
instant fluctuations in the sphingolipid biosynthetic flow.
CitacióCapasso, S. [et al.]. Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network. "EMBO Journal", 10 Abril 2017.
ISSN0261-4189
Versió de l'editorhttp://emboj.embopress.org/content/early/2017/05/10/embj.201696048
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EMBO accepted.pdf | 28,32Mb | Visualitza/Obre |