Sphingomyelin metabolism controls the shape and function of the Golgi cisternae
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Tipus de documentArticle
Data publicació2017-05-13
EditoreLife Sciences Publications
Condicions d'accésAccés obert
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
ProjecteDISPOSITIVOS DE NANO-ANTENAS FOTONICAS EN CELULAS VIVAS: INCREMENTANDO NUESTRO ENTENDIMIENTO EN LOS MECANISMOS MOLECULARES RESPONSABLES DE SALUD Y ENFERMEDAD (MINECO-FIS2014-56107-R)
NANO-VISTA - Advanced photonic antenna tools for biosensing and cellular nanoimaging (EC-FP7-288263)
MUPS - Mechanism of Unconventional Protein Secretion (EC-FP7-268692)
NANO-VISTA - Advanced photonic antenna tools for biosensing and cellular nanoimaging (EC-FP7-288263)
MUPS - Mechanism of Unconventional Protein Secretion (EC-FP7-268692)
Abstract
The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us to propose that sphingomyelin (SM) metabolism at the trans-Golgi membranes in mammalian cells essentially controls the structural features of a Golgi cisterna by regulating its association to curvature-generating proteins. An experimental test of this hypothesis revealed that affecting SM homeostasis converted flat cisternae into highly curled membranes with a concomitant dissociation of membrane curvature-generating proteins. These data lend support to our hypothesis that SM metabolism controls the structural organization of a Golgi cisterna. Together with our previously presented role of SM in controlling the location of proteins involved in glycosylation and vesicle formation, our data reveal the significance of SM metabolism in the structural organization and function of Golgi cisternae.
CitacióCampelo, F. [et al.]. Sphingomyelin metabolism controls the shape and function of the Golgi cisternae. "eLife", 13 Maig 2017.
ISSN2050-084X
Versió de l'editorhttps://elifesciences.org/content/6/e24603
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