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Noninvasive assessment of an engineered bioactive graft in myocardial infarction: impact on cardiac function and scar healing
dc.contributor.author | Gálvez Montón, Carolina |
dc.contributor.author | Bragós Bardia, Ramon |
dc.contributor.author | Soler Botija, Carolina |
dc.contributor.author | Díaz Güemes, Idoia |
dc.contributor.author | Prat Vidal, Cristina |
dc.contributor.author | Crisóstomo, Verónica |
dc.contributor.author | Sánchez Margallo, Francisco M. |
dc.contributor.author | Llucia Valldeperes, A. |
dc.contributor.author | Bogónez-Franco, Paco |
dc.contributor.author | Perea Gil, Isaac |
dc.contributor.author | Roura, Santiago |
dc.contributor.author | Bayés Genis, Antoni |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica |
dc.date.accessioned | 2017-05-12T12:38:13Z |
dc.date.available | 2017-05-12T12:38:13Z |
dc.date.issued | 2016-09-02 |
dc.identifier.citation | Gálvez, C., Bragos, R., Soler, C., Díaz-Gëmes, I., Prat, C., Crisóstomo, V., Sánchez-Margallo, F.M., Llucia, A., Bogónez-Franco, P., Perea, I., Roura, S., Bayés-Genis, A. Noninvasive assessment of an engineered bioactive graft in myocardial infarction: impact on cardiac function and scar healing. "Stem Cells Translational Medicine", 2 Setembre 2016, vol. sctm.2016-0063, núm. 5, p. 1-9. |
dc.identifier.issn | 2157-6564 |
dc.identifier.uri | http://hdl.handle.net/2117/104371 |
dc.description.abstract | Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in a swine MI model. The EBIG comprises a scaffold of decellularized human pericardium, green fluorescent protein-labeled porcine adipose tissue-derived progenitor cells (pATPCs), and a customized-design electrical impedance spectroscopy (EIS) monitoring system. Cardiac function was evaluated noninvasively by using magnetic resonance imaging (MRI). Scar healing was evaluated by using the EIS system within the implanted graft. Additionally, infarct size, fibrosis, and inflammation were explored by histopathology. Upon sacrifice 1 month after the intervention, MRI detected a significant improvement in left ventricular ejection fraction (7.5%64.9% vs. 1.4%63.7%; p = .038) and stroke volume (11.565.9 ml vs. 364.5 ml; p = .019) in EBIG-treated animals. Noninvasive EIS data analysis showed differences in both impedance magnitude ratio (20.02 6 0.04 per day vs. 20.48 6 0.07 per day; p = .002) and phase angle slope (20.18°60.24° per day vs.23.52°60.84° per day; p = .004) in EBIG compared with control animals. Moreover, in EBIG-treated animals, the infarct size was 48% smaller (3.4%60.6% vs. 6.5%61%; p = .015), less inflammation was found by means of CD25+ lymphocytes (0.65 6 0.12 vs. 1.26 6 0.2; p = .006), and a lower collagen I/III ratio was detected (0.4960.06 vs. 1.6660.5; p = .019). An EBIG composed of acellular pericardium refilled with pATPCs significantly reduced infarct size and improved cardiac function in a preclinical model of MI. Noninvasive EIS monitoring was useful for tracking differential scar healing in EBIG-treated animals, which was confirmed by less inflammation and altered collagen deposit. |
dc.format.extent | 9 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria electrònica::Instrumentació i mesura |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut |
dc.subject.lcsh | Biomedical materials |
dc.subject.lcsh | Myocardial infarction |
dc.subject.other | Myocardial infarction |
dc.subject.other | Bioimpedance |
dc.subject.other | Biomedical engineering |
dc.title | Noninvasive assessment of an engineered bioactive graft in myocardial infarction: impact on cardiac function and scar healing |
dc.type | Article |
dc.subject.lemac | Materials biomèdics |
dc.subject.lemac | Infart de miocardi |
dc.contributor.group | Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica |
dc.identifier.doi | 10.5966/sctm.2016-0063 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.5966/sctm.2016-0063/abstract;jsessionid=6D2ADECDE245E290A3FCEC4D4A0E1882.f04t02 |
dc.rights.access | Open Access |
local.identifier.drac | 19375937 |
dc.description.version | Postprint (published version) |
dc.relation.projectid | info:eu-repo/grantAgreement/MINECO//TEC2014-59995-R/ES/SERVICE-ORIENTED HYBRID OPTICAL NETWORK AND CLOUD INFRASTRUCTURE FEATURING HIGH THROUGHPUT AND ULTRA-LOW LATENCY/ |
local.citation.author | Gálvez, C.; Bragos, R.; Soler, C.; Díaz-Gëmes, I.; Prat, C.; Crisóstomo, V.; Sánchez-Margallo, F.M.; Llucia, A.; Bogónez-Franco, P.; Perea, I.; Roura, S.; Bayés-Genis, A. |
local.citation.publicationName | Stem Cells Translational Medicine |
local.citation.volume | sctm.2016-0063 |
local.citation.number | 5 |
local.citation.startingPage | 1 |
local.citation.endingPage | 9 |
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