Show simple item record

dc.contributor.authorStefanov, Ivaylo
dc.contributor.authorHoyo Pérez, Javier
dc.contributor.authorCailloux, Jonathan
dc.contributor.authorSantana Pérez, Orlando Onofre
dc.contributor.authorTzanov, Tzanko
dc.contributor.authorPérez Rafael, Silvia
dc.contributor.authorHinojosa-Caballero, Dolores
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2017-04-26T06:51:33Z
dc.date.available2019-04-19T00:30:24Z
dc.date.issued2017-04-19
dc.identifier.citationStefanov, I., Perez-Rafel, S., Hoyo, J., Cailloux, J., Santana, O., hinojosa-Caballero, D., Tzanov, T. Multifunctional enzymatically generated hydrogels for chronic wound application. "Biomacromolecules", 19 Abril 2017.
dc.identifier.issn1525-7797
dc.identifier.urihttp://hdl.handle.net/2117/103739
dc.description.abstractThe healing of chronic wounds requires intensive medical intervention at huge healthcare costs. Dressing materials should consider the multifactorial nature of these wounds comprising deleterious proteolytic and oxidative enzymes and high bacterial load. In this work, multifunctional hydrogels for chronic wound application were produced by enzymatic cross- linking of thiolated chitosan and gallic acid. The hydrogels combine several beneficial to wound healing properties, controlling the matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) activities, oxidative stress, and bacterial contamination. In vitro studies revealed above 90% antioxidant activity, and MPO and collagenase inhibition by up to 98 and 23%, respectively. Ex vivo studies with venous leg ulcer exudates confirmed the inhibitory capacity of the dressings against MPO and MMPs. Additionally, the hydrogels reduced the population of the most frequently encountered in nonhealing wounds bacterial strains. The stable at physiological conditions and resistant to lysozyme degradation hydrogels showed high biocompatibility with human skin fibroblasts
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshColloids in medicine
dc.titleMultifunctional enzymatically generated hydrogels for chronic wound application
dc.typeArticle
dc.subject.lemacCol·loides en medicina
dc.contributor.groupUniversitat Politècnica de Catalunya. POLY2 - Polyfunctional polymeric materials
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.1021/acs.biomac.7b00111
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
local.identifier.drac20093068
dc.description.versionPostprint (author's final draft)
local.citation.authorStefanov, I.; Hoyo, J.; Cailloux, J.; Santana, O.; Tzanov, T.
local.citation.publicationNameBiomacromolecules


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record