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Multifunctional enzymatically generated hydrogels for chronic wound application

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Hydrogels+for+chronic+wound.pdf (1,227Mb)
 
10.1021/acs.biomac.7b00111
 
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hdl:2117/103739

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Stefanov, Ivaylo
Hoyo Pérez, JavierMés informacióMés informació
Cailloux, JonathanMés informacióMés informació
Santana Pérez, Orlando OnofreMés informacióMés informacióMés informació
Tzanov, TzankoMés informacióMés informacióMés informació
Pérez Rafael, SilviaMés informacióMés informacióMés informació
Hinojosa-Caballero, Dolores
Document typeArticle
Defense date2017-04-19
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
The healing of chronic wounds requires intensive medical intervention at huge healthcare costs. Dressing materials should consider the multifactorial nature of these wounds comprising deleterious proteolytic and oxidative enzymes and high bacterial load. In this work, multifunctional hydrogels for chronic wound application were produced by enzymatic cross- linking of thiolated chitosan and gallic acid. The hydrogels combine several beneficial to wound healing properties, controlling the matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) activities, oxidative stress, and bacterial contamination. In vitro studies revealed above 90% antioxidant activity, and MPO and collagenase inhibition by up to 98 and 23%, respectively. Ex vivo studies with venous leg ulcer exudates confirmed the inhibitory capacity of the dressings against MPO and MMPs. Additionally, the hydrogels reduced the population of the most frequently encountered in nonhealing wounds bacterial strains. The stable at physiological conditions and resistant to lysozyme degradation hydrogels showed high biocompatibility with human skin fibroblasts
CitationStefanov, I., Perez-Rafel, S., Hoyo, J., Cailloux, J., Santana, O., hinojosa-Caballero, D., Tzanov, T. Multifunctional enzymatically generated hydrogels for chronic wound application. "Biomacromolecules", 19 Abril 2017. 
URIhttp://hdl.handle.net/2117/103739
DOI10.1021/acs.biomac.7b00111
ISSN1525-7797
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  • GBMI - Grup de Biotecnologia Molecular i Industrial - Articles de revista [210]
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [960]
  • POLY2 - Polyfunctional polymeric materials - Articles de revista [114]
  • Departament d'Enginyeria Química - Articles de revista [2.441]
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