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dc.contributor.authorSáez Viñas, Pablo
dc.contributor.authorPena, Estefanía
dc.contributor.authorDoblaré, Manuel
dc.contributor.authorMartínez, Miguel Ángel
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental
dc.identifier.citationSaez, P., Pena, E., Doblaré, M., Martínez, M.A. An anisotropic microsphere-based approach for fiber orientation adaptation in soft tissue. "IEEE transactions on biomedical engineering", 2011, vol. 58, núm. 12, p. 3500-3503.
dc.description.abstractEvolutionary processes in biological tissue, such as adaptation or remodeling, represent an enterprising area of research. In this paper, we present a multiscale model for the remodeling of fibered structures, such as bundles of collagen fibrils. With this aim, we introduce a von Mises statistical distribution function to account for the directional dispersion of the fibrils, and we remodel the underlying fibrils by changing their orientation. To numerically compute this process, we make use of the microsphere approach, which provides a useful multiscale tool for homogenizing the microstructure behavior, related to the fibrils of the bundle, in the macroscale of the problem. The results show how the fibrils respond to the stimulus by reorientation of their structure. This process leads to a stiffer material eventually reaching a stationary state. These results are in agreement with those reported in the literature, and they characterize the adaptation of biological tissue to external stimuli.
dc.format.extent4 p.
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Investigació operativa::Simulació
dc.subject.lcshStrength of materials
dc.titleAn anisotropic microsphere-based approach for fiber orientation adaptation in soft tissue
dc.subject.lemacResistència de materials
dc.contributor.groupUniversitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::74 Mechanics of deformable solids::74P Optimization
dc.subject.amsClassificació AMS::74 Mechanics of deformable solids::74B Elastic materials
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorSaez, P.; Pena, E.; Doblaré, M.; Martínez, M.A.
upcommons.citation.publicationNameIEEE transactions on biomedical engineering

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