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dc.contributor.authorSáez Viñas, Pablo
dc.contributor.authorPeña, Estefanía
dc.contributor.authorMartínez, Miguel Ángel
dc.contributor.authorKuhl, Ellen
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental
dc.identifier.citationSaez, P., Peña, E., Martínez, M., Kuhl, E. Computational modeling of hypertensive growth in the human carotid artery. "Computational mechanics", Juny 2014, vol. 53, núm. 6, p. 1183-1196.
dc.descriptionThe final publication is available at Springer via
dc.description.abstractArterial hypertension is a chronic medical condition associated with an elevated blood pressure. Chronic arterial hypertension initiates a series of events, which are known to collectively initiate arterial wall thickening. However, the correlation between macrostructural mechanical loading, microstructural cellular changes, and macrostructural adaptation remains unclear. Here, we present a microstructurally motivated computational model for chronic arterial hypertension through smooth muscle cell growth. To model growth, we adopt a classical concept based on the multiplicative decomposition of the deformation gradient into an elastic part and a growth part. Motivated by clinical observations, we assume that the driving force for growth is the stretch sensed by the smooth muscle cells. We embed our model into a finite element framework, where growth is stored locally as an internal variable. First, to demonstrate the features of our model, we investigate the effects of hypertensive growth in a real human carotid artery. Our results agree nicely with experimental data reported in the literature both qualitatively and quantitatively.
dc.format.extent14 p.
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat
dc.subject.lcshCombinatorial probabilities
dc.subject.otherSmooth muscle cells
dc.subject.otherFinite element method
dc.titleComputational modeling of hypertensive growth in the human carotid artery
dc.contributor.groupUniversitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
dc.subject.amsClassificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorSaez, P., Peña, E., Martínez, M., Kuhl, E.
upcommons.citation.publicationNameComputational mechanics

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