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dc.contributor.authorHernández-Vega, Amayra
dc.contributor.authorMarsal, María
dc.contributor.authorPouille, Philippe-Alexandre
dc.contributor.authorTosi, Sebastien
dc.contributor.authorColombelli, Julien
dc.contributor.authorLuque, Tomás
dc.contributor.authorNavajas, Daniel
dc.contributor.authorPagonabarraga, Ignacio
dc.contributor.authorMartín-Blanco, Enrique
dc.contributor.otherUniversitat Politècnica de Catalunya. Institut de Ciències Fotòniques
dc.date.accessioned2017-03-29T11:00:58Z
dc.date.available2017-05-09T00:30:37Z
dc.date.issued2016-11-09
dc.identifier.citationHernández-Vega, A. [et al.]. Polarized cortical tension drives zebrafish epiboly movements. "EMBO Journal", 9 Novembre 2016, vol. 36, núm. 1, p. 25-41.
dc.identifier.issn0261-4189
dc.identifier.urihttp://hdl.handle.net/2117/103032
dc.description.abstractThe principles underlying the biomechanics of morphogenesis are largely unknown. Epiboly is an essential embryonic event in which three tissues coordinate to direct the expansion of the blastoderm. How and where forces are generated during epiboly, and how these are globally coupled remains elusive. Here we developed a method, hydrodynamic regression (HR), to infer 3D pressure fields, mechanical power, and cortical surface tension profiles. HR is based on velocity measurements retrieved from 2D+T microscopy and their hydrodynamic modeling. We applied HR to identify biomechanically active structures and changes in cortex local tension during epiboly in zebrafish. Based on our results, we propose a novel physical description for epiboly, where tissue movements are directed by a polarized gradient of cortical tension. We found that this gradient relies on local contractile forces at the cortex, differences in elastic properties between cortex components and the passive transmission of forces within the yolk cell. All in all, our work identifies a novel way to physically regulate concerted cellular movements that might be instrumental for the mechanical control of many morphogenetic processes.
dc.language.isoeng
dc.publisherEMBOpress
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshHydrodynamics
dc.subject.otherepiboly
dc.titlePolarized cortical tension drives zebrafish epiboly movements
dc.typeArticle
dc.subject.lemacHidrodinàmica
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://emboj.embopress.org/content/early/2016/11/09/embj.201694264
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
upcommons.citation.publishedtrue
upcommons.citation.publicationNameEMBO Journal
upcommons.citation.volume36
upcommons.citation.number1
upcommons.citation.startingPage25
upcommons.citation.endingPage41


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