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Ultrasensitive interferometric on-chip microscopy of transparent objects

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Terborg, Roland A.
Pello, Josselin
Mannelli, Llaria
Pérez Torres, JuanMés informacióMés informacióMés informació
Pruneri, Valerio
Document typeArticle
Defense date2016-06
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
ProjectRAIS - Scalable, point-of-care and label free microarray platform for rapid detection of Sepsis (EC-H2020-644956)
Abstract
Light microscopes can detect objects through several physical processes, such as scattering, absorption, and reflection. In transparent objects, these mechanisms are often too weak, and interference effects are more suitable to observe the tiny refractive index variations that produce phase shifts. We propose an on-chip microscope design that exploits birefringence in an unconventional geometry. It makes use of two sheared and quasi-overlapped illuminating beams experiencing relative phase shifts when going through the object, and a complementary metal-oxide-semiconductor image sensor array to record the resulting interference pattern. Unlike conventional microscopes, the beams are unfocused, leading to a very large field of view (20 mm(2)) and detection volume (more than 0.5 cm(3)), at the expense of lateral resolution. The high axial sensitivity (<1 nm) achieved using a novel phase-shifting interferometric operation makes the proposed device ideal for examining transparent substrates and reading microarrays of biomarkers. This is demonstrated by detecting nanometer-thick surface modulations on glass and single and double protein layers.
CitationTerborg, R., Pello, J., Mannelli, I., Juan P. Torres, Pruneri, V. Ultrasensitive interferometric on-chip microscopy of transparent objects. "Science advances", Juny 2016, vol. 2, núm. 6, p. 1-8. 
URIhttp://hdl.handle.net/2117/102826
DOI10.1126/sciadv.1600077
ISSN2375-2548
Publisher versionhttp://advances.sciencemag.org/content/2/6/e1600077
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