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Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome
dc.contributor.author | Catuara-Solarz, Silvina |
dc.contributor.author | Espinoa Carrasco, Jose |
dc.contributor.author | Erb, Ionas |
dc.contributor.author | Langohr, Klaus |
dc.contributor.author | González, Juan Ramon |
dc.contributor.author | Notredame, Cedric |
dc.contributor.author | Dierssen, Mara |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa |
dc.date.accessioned | 2017-03-21T18:47:56Z |
dc.date.available | 2017-03-21T18:47:56Z |
dc.date.issued | 2016-11-08 |
dc.identifier.citation | Catuara-Solarz, S., Espinoa, J., Erb, I., Langohr, K., González, J., Notredame, C., Dierssen, M. Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome. "eNeuro", 8 Novembre 2016, vol. 3, núm. 5, p. 1-18. |
dc.identifier.issn | 2373-2822 |
dc.identifier.uri | http://hdl.handle.net/2117/102765 |
dc.description.abstract | Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown. Here, we explored the effects of a combined therapy with environmental enrichment (EE) and EGCG in the Ts65Dn mouse model of DS at young age. Our results show that combined EE-EGCG treatment improved corticohippocampal-dependent learning and memory. Cognitive improvements were accompanied by a rescue of cornu ammonis 1 (CA1) dendritic spine density and a normalization of the proportion of excitatory and inhibitory synaptic markers in CA1 and dentate gyrus. |
dc.format.extent | 18 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant |
dc.subject.lcsh | Combinatorial probabilities |
dc.subject.lcsh | Multivariate analysis |
dc.subject.lcsh | Sampling (Statistics) |
dc.subject.other | (-)-epigallocatechin-3-gallate |
dc.subject.other | down Syndrome |
dc.subject.other | Environmental Enrichment |
dc.subject.other | Excitation-Inhibition Imbalance |
dc.subject.other | neuroplasticity |
dc.title | Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome |
dc.type | Article |
dc.subject.lemac | Probabilitats |
dc.subject.lemac | Anàlisi multivariable |
dc.subject.lemac | Mostreig (Estadística) |
dc.contributor.group | Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica |
dc.identifier.doi | 10.1523/ENEURO.0103-16.2016 |
dc.description.peerreviewed | Peer Reviewed |
dc.subject.ams | Classificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability |
dc.subject.ams | Classificació AMS::62 Statistics::62H Multivariate analysis |
dc.subject.ams | Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys |
dc.relation.publisherversion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099603/ |
dc.rights.access | Open Access |
local.identifier.drac | 19688860 |
dc.description.version | Postprint (published version) |
local.citation.author | Catuara-Solarz, S.; Espinoa, J.; Erb, I.; Langohr, K.; González, J.; Notredame, C.; Dierssen, M. |
local.citation.publicationName | eNeuro |
local.citation.volume | 3 |
local.citation.number | 5 |
local.citation.startingPage | 1 |
local.citation.endingPage | 18 |
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