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dc.contributor.authorCatuara-Solarz, Silvina
dc.contributor.authorEspinoa Carrasco, Jose
dc.contributor.authorErb, Ionas
dc.contributor.authorLangohr, Klaus
dc.contributor.authorGonzález, Juan Ramon
dc.contributor.authorNotredame, Cedric
dc.contributor.authorDierssen, Mara
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.identifier.citationCatuara-Solarz, S., Espinoa, J., Erb, I., Langohr, K., González, J., Notredame, C., Dierssen, M. Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome. "eNeuro", 8 Novembre 2016, vol. 3, núm. 5, p. 1-18.
dc.description.abstractIntellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown. Here, we explored the effects of a combined therapy with environmental enrichment (EE) and EGCG in the Ts65Dn mouse model of DS at young age. Our results show that combined EE-EGCG treatment improved corticohippocampal-dependent learning and memory. Cognitive improvements were accompanied by a rescue of cornu ammonis 1 (CA1) dendritic spine density and a normalization of the proportion of excitatory and inhibitory synaptic markers in CA1 and dentate gyrus.
dc.format.extent18 p.
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant
dc.subject.lcshCombinatorial probabilities
dc.subject.lcshMultivariate analysis
dc.subject.lcshSampling (Statistics)
dc.subject.otherdown Syndrome
dc.subject.otherEnvironmental Enrichment
dc.subject.otherExcitation-Inhibition Imbalance
dc.titleCombined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome
dc.subject.lemacAnàlisi multivariable
dc.subject.lemacMostreig (Estadística)
dc.contributor.groupUniversitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability
dc.subject.amsClassificació AMS::62 Statistics::62H Multivariate analysis
dc.subject.amsClassificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
dc.rights.accessOpen Access
dc.description.versionPostprint (published version)
local.citation.authorCatuara-Solarz, S.; Espinoa, J.; Erb, I.; Langohr, K.; González, J.; Notredame, C.; Dierssen, M.

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