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dc.contributor.authorDel Valle Mendoza, Juana
dc.contributor.authorPumarola, Tomas
dc.contributor.authorAlzamora Gonzales, Libertad
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2017-03-16T11:33:25Z
dc.date.available2017-03-16T11:33:25Z
dc.date.issued2014
dc.identifier.citationDel Valle, J., Pumarola, T., Alzamora, L., del Valle, L. Antiviral activity of maca (Lepidium meyenii) against human influenza virus. "Asian Pacific Journal of Tropical Medicine", 2014, vol. 7, núm. Suppl 1, p. S415-S420.
dc.identifier.issn1995-7645
dc.identifier.urihttp://hdl.handle.net/2117/102577
dc.description.abstractObjective To investigate antiviral activity of maca to reduce viral load in Madin-Darby canine kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and Flu-B, respectively). Methods Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the extracts were evaluated on MDCK cells using method MTT assay. Antiviral activity of compounds against Flu-A and Flu-B viruses was assayed using a test for determining the inhibition of the cytopathic effect on cell culture and multiplex RT-PCR. Results The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshAntiviral agents
dc.subject.lcshMaca (Plant)
dc.subject.otherInfluenza virus
dc.subject.otherFlu
dc.subject.otherAntiviral activity
dc.subject.otherLepidium meyenii
dc.subject.otherMaca
dc.titleAntiviral activity of maca (Lepidium meyenii) against human influenza virus
dc.typeArticle
dc.subject.lemacVirus
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.identifier.doi10.1016/S1995-7645(14)60268-6
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.journals.elsevier.com/asian-pacific-journal-of-tropical-medicine
dc.rights.accessOpen Access
local.identifier.drac19790027
dc.description.versionPostprint (author's final draft)
local.citation.authorDel Valle, J.; Pumarola, T.; Alzamora, L.; del Valle, LJ.
local.citation.publicationNameAsian Pacific Journal of Tropical Medicine
local.citation.volume7
local.citation.numberSuppl 1
local.citation.startingPageS415
local.citation.endingPageS420


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