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dc.contributor.authorOchoa Gómez, John Fredy
dc.contributor.authorAlonso López, Joan Francesc
dc.contributor.authorDuque, Jon
dc.contributor.authorTobón, Carlos
dc.contributor.authorMañanas Villanueva, Miguel Ángel
dc.contributor.authorLopera, Francisco
dc.contributor.authorHernández Valdivieso, Alher Mauricio
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.date.accessioned2017-03-16T10:17:18Z
dc.date.available2017-03-16T10:17:18Z
dc.date.issued2017-01-01
dc.identifier.citationOchoa, J. F., Alonso, J.F., Duque, J., Tobón, C., Mañanas, M.A., Lopera, F., Hernández, A. Successful object encoding induces increased directed connectivity in presymptomatic early-onset Alzheimer's disease. "Journal of alzheimers disease", 1 Gener 2017, vol. 55, núm. 3, p. 1195-1205.
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/2117/102564
dc.description.abstractBackground: Recent studies report increases in neural activity in brain regions critical to episodic memory at preclinical stages of Alzheimer’s disease (AD). Although electroencephalography (EEG) is widely used in AD studies, given its non-invasiveness and low cost, there is a need to translate the findings in other neuroimaging methods to EEG. Objective: To examine how the previous findings using functional magnetic resonance imaging (fMRI) at preclinical stage in presenilin-1 E280A mutation carriers could be assessed and extended, using EEG and a connectivity approach. Methods: EEG signals were acquired during resting and encoding in 30 normal cognitive young subjects, from an autosomal dominant early-onset AD kindred from Antioquia, Colombia. Regions of the brain previously reported as hyperactive were used for connectivity analysis. Results: Mutation carriers exhibited increasing connectivity at analyzed regions. Among them, the right precuneus exhibited the highest changes in connectivity. Conclusion: Increased connectivity in hyperactive cerebral regions is seen in individuals, genetically-determined to develop AD, at preclinical stage. The use of a connectivity approach and a widely available neuroimaging technique opens the possibility to increase the use of EEG in early detection of preclinical AD.
dc.format.extent11 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshBiomedical engineering
dc.subject.otherAlzheimer's disease
dc.subject.otherautosomal-dominant
dc.subject.otherelectroencephalography
dc.subject.otherfunctional neuroimaging
dc.subject.othermemory encoding
dc.subject.otherpresenilin-1
dc.titleSuccessful object encoding induces increased directed connectivity in presymptomatic early-onset Alzheimer's disease
dc.typeArticle
dc.subject.lemacBioenginyeria
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOART - BIOsignal Analysis for Rehabilitation and Therapy
dc.identifier.doi10.3233/JAD-160803
dc.relation.publisherversionhttp://content.iospress.com/articles/journal-of-alzheimers-disease/jad160803
dc.rights.accessOpen Access
drac.iddocument19672243
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorOchoa, J. F., Alonso, J.F., Duque, J., Tobón, C., Mañanas, M.A., Lopera, F., Hernández, A.M.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameJournal of alzheimers disease
upcommons.citation.volume55
upcommons.citation.number3
upcommons.citation.startingPage1195
upcommons.citation.endingPage1205


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