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dc.contributor.authorMas Moruno, Carlos
dc.contributor.authorFraioli, Roberta
dc.contributor.authorRechenmacher, Florian
dc.contributor.authorNeubauer, Stefanie
dc.contributor.authorKapp, Tobias G.
dc.contributor.authorKessler, Horst
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2017-03-15T11:28:08Z
dc.date.available2018-06-05T00:31:29Z
dc.date.issued2016-06-13
dc.identifier.citationMas-Moruno, C., Fraioli, R., Rechenmacher, F., Neubauer, S., Kapp, T., Kessler, H. avß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating. "Angewandte chemie. International edition", 13 Juny 2016, vol. 55, núm. 25, p. 7048-7067.
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/2117/102501
dc.description.abstractEngineering biomaterials with integrin-binding activity is a very powerful approach to promote cell adhesion, modulate cell behavior, and induce specific biological responses at the surface level. The aim of this Review is to illustrate the evolution of surface-coating molecules in this field: from peptides and proteins with relatively low integrin-binding activity and receptor selectivity to highly active and selective peptidomimetic ligands. In particular, we will bring into focus the difficult challenge of achieving selectivity between the two closely related integrin subtypes avß3 and a5ß1. The functionalization of surfaces with such peptidomimetics opens the way for a new generation of highly specific cell-instructive surfaces to dissect the biological role of integrin subtypes and for application in tissue engineering and regenerative medicine.
dc.format.extent20 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshBiomedical engineering
dc.subject.lcshPeptides
dc.subject.lcshProteins
dc.subject.lcshTissue engineering
dc.subject.otherIntegrins
dc.subject.otherpeptidomimetics
dc.subject.otherreceptor selectivity
dc.subject.otherRGD peptides
dc.subject.othersurface coating
dc.titleavß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating
dc.typeArticle
dc.subject.lemacEnginyeria biomèdica
dc.subject.lemacPèptids
dc.subject.lemacProteïnes
dc.subject.lemacEnginyeria de teixits
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1002/anie.201509782
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201509782/abstract
dc.rights.accessOpen Access
drac.iddocument19702731
dc.description.versionPostprint (author's final draft)
dc.contributor.covenanteeTechnische Universität München
upcommons.citation.authorMas-Moruno, C., Fraioli, R., Rechenmacher, F., Neubauer, S., Kapp, T., Kessler, H.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameAngewandte chemie. International edition
upcommons.citation.volume55
upcommons.citation.number25
upcommons.citation.startingPage7048
upcommons.citation.endingPage7067


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