avß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating

Cita com:
hdl:2117/102501
CovenanteeTechnische Universität München
Document typeArticle
Defense date2016-06-13
Rights accessOpen Access
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Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Engineering biomaterials with integrin-binding activity is a very powerful approach to promote cell adhesion, modulate cell behavior, and induce specific biological responses at the surface level. The aim of this Review is to illustrate the evolution of surface-coating molecules in this field: from peptides and proteins with relatively low integrin-binding activity and receptor selectivity to highly active and selective peptidomimetic ligands. In particular, we will bring into focus the difficult challenge of achieving selectivity between the two closely related integrin subtypes avß3 and a5ß1. The functionalization of surfaces with such peptidomimetics opens the way for a new generation of highly specific cell-instructive surfaces to dissect the biological role of integrin subtypes and for application in tissue engineering and regenerative medicine.
CitationMas-Moruno, C., Fraioli, R., Rechenmacher, F., Neubauer, S., Kapp, T., Kessler, H. avß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating. "Angewandte chemie. International edition", 13 Juny 2016, vol. 55, núm. 25, p. 7048-7067.
ISSN1433-7851
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201509782/abstract
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