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A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins
dc.contributor.author | Kapp, Tobias G. |
dc.contributor.author | Rechenmacher, Florian |
dc.contributor.author | Neubauer, Stefanie |
dc.contributor.author | Maltsev, Oleg V. |
dc.contributor.author | Cavalcanti-Adam, Elisabetta Ada |
dc.contributor.author | Zarka, Revital |
dc.contributor.author | Reuning, Ute |
dc.contributor.author | Notni, Johannes |
dc.contributor.author | Wester, Hans-Jürgen |
dc.contributor.author | Mas Moruno, Carlos |
dc.contributor.author | Spatz, Joachim |
dc.contributor.author | Geiger, Benjamin |
dc.contributor.author | Kessler, Horst |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2017-03-15T08:35:56Z |
dc.date.available | 2017-03-15T08:35:56Z |
dc.date.issued | 2017-01-11 |
dc.identifier.citation | Kapp, T., Rechenmacher, F., Neubauer, S., Maltsev, O., Cavalcanti-Adam, E., Zarka, R., Reuning, U., Notni, J., Wester, H.J., Mas-Moruno, C., Spatz, J., Geiger, B., Kessler, H. A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. "Scientific reports", 11 Gener 2017, vol. 7. |
dc.identifier.issn | 2045-2322 |
dc.identifier.uri | http://hdl.handle.net/2117/102476 |
dc.description.abstract | Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In the last decades, many integrin-specific ligands have been developed and used for modulation of integrin function in medical as well as biophysical studies. The IC50-values reported for these ligands strongly vary and are measured using different cell-based and cell-free systems. A systematic comparison of these values is of high importance for selecting the optimal ligands for given applications. In this study, we evaluate a wide range of ligands for their binding affinity towards the RGD-binding integrins avß3, avß5, avß6, avß8, a5ß1, aIIbß3, using homogenous ELISA-like solid phase binding assay. |
dc.language.iso | eng |
dc.publisher | Macmillan Publishers |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials |
dc.subject.lcsh | Tissue engineering |
dc.title | A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins |
dc.type | Article |
dc.subject.lemac | Enginyeria de teixits |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1038/srep39805 |
dc.relation.publisherversion | http://www.nature.com/articles/srep39805 |
dc.rights.access | Open Access |
local.identifier.drac | 19681538 |
dc.description.version | Postprint (published version) |
dc.contributor.covenantee | Technische Universität München |
local.citation.author | Kapp, T.; Rechenmacher, F.; Neubauer, S.; Maltsev, O.; Cavalcanti-Adam, E.; Zarka, R.; Reuning, U.; Notni, J.; Wester, H.J.; Mas-Moruno, C.; Spatz, J.; Geiger, B.; Kessler, H. |
local.citation.publicationName | Scientific reports |
local.citation.volume | 7 |
dc.identifier.pmid | 28074920 |
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