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Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene
dc.contributor.author | Puiggalí Jou, Anna |
dc.contributor.author | Valle Mendoza, Luis Javier del |
dc.contributor.author | Armelín Diggroc, Elaine Aparecida |
dc.contributor.author | Alemán Llansó, Carlos |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2017-03-08T13:08:09Z |
dc.date.available | 2017-07-01T00:30:30Z |
dc.date.issued | 2016-10 |
dc.identifier.citation | Puiggali, A., del Valle, LJ., Armelin, E., Aleman, C. Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene. "Macromolecular bioscience", Octubre 2016, vol. 16, núm. 10, p. 1461-1474. |
dc.identifier.issn | 1616-5187 |
dc.identifier.uri | http://hdl.handle.net/2117/102130 |
dc.description.abstract | The properties as biointerfaces of electroactive conducting polymer-peptide biocomposites formed by poly(3,4-ethylenedioxythiophene) (PEDOT) and CREKA or CR(NMe)EKA peptide sequences (where Glu has been replaced by N-methyl-Glu in the latter) have been compared. CREKA is a linear pentapeptide that recognizes clotted plasma proteins and selectively homes to tumors, while CR(NMe)EKA is an engineer to improve such properties by altering peptide-fibrin interactions. Differences between PEDOT-CREKA and PEDOT-CR(NMe)EKA reflect dissemblance in the organization of the peptides into the polymeric matrix. Both peptides affect fibrinogen thrombin-catalyzed polymerization causing the immediate formation of fibrin, whereas in the absence of thrombin this phenomenon is only observed for CR(NMe)EKA. Consistently, the fibrin-adsorption capacity is higher for PEDOT-CR(NMe)EKA than for PEDOT-CREKA, even though in both cases adsorbed fibrin exhibits round-like morphologies rather than the characteristic fibrous structure. PEDOT-peptide films coated with fibrin are selective in terms of cell adhesion, promoting the attachment of metastatic cells with respect to normal cells. |
dc.format.extent | 14 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Peptides |
dc.subject.lcsh | Polymers |
dc.subject.lcsh | Biological interfaces |
dc.subject.other | cell differentiation |
dc.subject.other | electroactive polymers |
dc.subject.other | fibrin adsorption |
dc.subject.other | peptide-polymer composites |
dc.subject.other | poly(3 |
dc.subject.other | 4-ethylenedi-oxythiophene) |
dc.subject.other | ray photoelectron-spectroscopy |
dc.subject.other | conducting polymer |
dc.subject.other | biomedical applications |
dc.subject.other | derivatives |
dc.subject.other | composites |
dc.subject.other | pentapeptide |
dc.subject.other | proteins |
dc.subject.other | cancer |
dc.title | Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene |
dc.type | Article |
dc.subject.lemac | Pèptids |
dc.subject.lemac | Polímers -- Biocompatibilitat |
dc.contributor.group | Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
dc.contributor.group | Universitat Politècnica de Catalunya. IMEM - Innovació, Modelització i Enginyeria en (BIO) Materials |
dc.identifier.doi | 10.1002/mabi.201600128 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/mabi.201600128/abstract |
dc.rights.access | Open Access |
local.identifier.drac | 19672416 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Puiggali, A.; del Valle, LJ.; Armelin, E.; Aleman, C. |
local.citation.publicationName | Macromolecular bioscience |
local.citation.volume | 16 |
local.citation.number | 10 |
local.citation.startingPage | 1461 |
local.citation.endingPage | 1474 |
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