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Intercalative DNA binding of the marine anticancer drug variolin B
dc.contributor.author | Canals, Albert |
dc.contributor.author | Arribas Bosacoma, Raquel |
dc.contributor.author | Albericio Palomera, Fernando |
dc.contributor.author | Alvarez Domingo, Mercedes |
dc.contributor.author | Aymami Bofarull, Juan |
dc.contributor.author | Coll, Miquel |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2017-03-08T12:40:28Z |
dc.date.available | 2017-03-08T12:40:28Z |
dc.date.issued | 2017-01-04 |
dc.identifier.citation | Canals, A., Arribas-Bosacoma, R., Albericio, F., Alvarez-Domingo, M., Aymami, J., Coll, M. Intercalative DNA binding of the marine anticancer drug variolin B. "Scientific reports", 4 Gener 2017, vol. 7. |
dc.identifier.issn | 2045-2322 |
dc.identifier.uri | http://hdl.handle.net/2117/102126 |
dc.description.abstract | Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms. |
dc.language.iso | eng |
dc.publisher | Macmillan Publishers |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Alkaloids |
dc.subject.lcsh | Crystals--Structure |
dc.subject.lcsh | DNA |
dc.title | Intercalative DNA binding of the marine anticancer drug variolin B |
dc.type | Article |
dc.subject.lemac | Alcaloides |
dc.subject.lemac | Cristalls -- Estructura |
dc.subject.lemac | ADN |
dc.contributor.group | Universitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques |
dc.identifier.doi | 10.1038/srep39680 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.nature.com/articles/srep39680 |
dc.rights.access | Open Access |
local.identifier.drac | 19668183 |
dc.description.version | Postprint (published version) |
local.citation.author | Canals, A.; Arribas-Bosacoma, R.; Albericio, F.; Alvarez-Domingo, M.; Aymami, J.; Coll, M. |
local.citation.publicationName | Scientific reports |
local.citation.volume | 7 |
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