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dc.contributor.authorCanals, Albert
dc.contributor.authorArribas Bosacoma, Raquel
dc.contributor.authorAlbericio Palomera, Fernando
dc.contributor.authorAlvarez Domingo, Mercedes
dc.contributor.authorAymami Bofarull, Juan
dc.contributor.authorColl, Miquel
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2017-03-08T12:40:28Z
dc.date.available2017-03-08T12:40:28Z
dc.date.issued2017-01-04
dc.identifier.citationCanals, A., Arribas-Bosacoma, R., Albericio, F., Alvarez-Domingo, M., Aymami, J., Coll, M. Intercalative DNA binding of the marine anticancer drug variolin B. "Scientific reports", 4 Gener 2017, vol. 7.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/2117/102126
dc.description.abstractVariolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.
dc.language.isoeng
dc.publisherMacmillan Publishers
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshAlkaloids
dc.subject.lcshCrystals--Structure
dc.subject.lcshDNA
dc.titleIntercalative DNA binding of the marine anticancer drug variolin B
dc.typeArticle
dc.subject.lemacAlcaloides
dc.subject.lemacCristalls -- Estructura
dc.subject.lemacADN
dc.contributor.groupUniversitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques
dc.identifier.doi10.1038/srep39680
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.nature.com/articles/srep39680
dc.rights.accessOpen Access
drac.iddocument19668183
dc.description.versionPostprint (published version)
upcommons.citation.authorCanals, A., Arribas-Bosacoma, R., Albericio, F., Alvarez-Domingo, M., Aymami, J., Coll, M.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameScientific reports
upcommons.citation.volume7


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