Intercalative DNA binding of the marine anticancer drug variolin B
Cita com:
hdl:2117/102126
Tipus de documentArticle
Data publicació2017-01-04
EditorMacmillan Publishers
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.
CitacióCanals, A., Arribas-Bosacoma, R., Albericio, F., Alvarez-Domingo, M., Aymami, J., Coll, M. Intercalative DNA binding of the marine anticancer drug variolin B. "Scientific reports", 4 Gener 2017, vol. 7.
ISSN2045-2322
Versió de l'editorhttp://www.nature.com/articles/srep39680
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
srep39680 (2).pdf | Intercalative DNA binding of the marine anticancer drug variolin B | 725,0Kb | Visualitza/Obre |