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Intercalative DNA binding of the marine anticancer drug variolin B

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Intercalative DNA binding of the marine anticancer drug variolin B (725,0Kb)
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10.1038/srep39680
 
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hdl:2117/102126

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Canals, Albert
Arribas Bosacoma, Raquel
Albericio Palomera, Fernando
Alvarez Domingo, Mercedes
Aymami Bofarull, JuanMés informacióMés informació
Coll, Miquel
Document typeArticle
Defense date2017-01-04
PublisherMacmillan Publishers
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.
CitationCanals, A., Arribas-Bosacoma, R., Albericio, F., Alvarez-Domingo, M., Aymami, J., Coll, M. Intercalative DNA binding of the marine anticancer drug variolin B. "Scientific reports", 4 Gener 2017, vol. 7. 
URIhttp://hdl.handle.net/2117/102126
DOI10.1038/srep39680
ISSN2045-2322
Publisher versionhttp://www.nature.com/articles/srep39680
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  • MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques - Articles de revista [29]
  • Departament d'Enginyeria Química - Articles de revista [2.068]
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