Intercalative DNA binding of the marine anticancer drug variolin B
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Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.
CitationCanals, A., Arribas-Bosacoma, R., Albericio, F., Alvarez-Domingo, M., Aymami, J., Coll, M. Intercalative DNA binding of the marine anticancer drug variolin B. "Scientific reports", 4 Gener 2017, vol. 7.