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dc.contributor.authorBendezú García, Álvaro
dc.contributor.authorMego, Marianela
dc.contributor.authorMonclús Lahoya, Eva
dc.contributor.authorMerino, Xavi
dc.contributor.authorAccarino Garaventa, Anna María
dc.contributor.authorMalagelada Benapres, Juan Ramon
dc.contributor.authorNavazo Álvaro, Isabel
dc.contributor.authorAzpiroz Vidaur, Fernando
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciències de la Computació
dc.date.accessioned2017-03-06T15:27:45Z
dc.date.available2018-01-30T01:30:19Z
dc.date.issued2017-01-29
dc.identifier.citationBendezú, Á., Mego, M., Monclús, E., Merino, X., Accarino, A., Malagelada, J., Navazo, I., Azpiroz, F. Colonic content: effect of diet, meals, and defecation. "Neurogastroenterology and motility", Febrer 2017, vol. 29, núm. 2.
dc.identifier.issn1350-1925
dc.identifier.urihttp://hdl.handle.net/2117/101976
dc.descriptionThis is the peer reviewed version of the following article: Bendezú, Á., Mego, M., Monclús, E., Merino, X., Accarino, A., Malagelada, J., Navazo, I., Azpiroz, F. Colonic content: effect of diet, meals, and defecation. "Neurogastroenterology and motility", Febrer 2017, vol. 29, núm. 2, which has been published in final form at [http://onlinelibrary.wiley.com.recursos.biblioteca.upc.edu/doi/10.1111/nmo.12930/full]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.description.abstractThe metabolic activity of colonic microbiota is influenced by diet; however, the relationship between metabolism and colonic content is not known. Our aim was to determine the effect of meals, defecation, and diet on colonic content. Methods: In 10 healthy subjects, two abdominal MRI scans were acquired during fasting, 1 week apart, and after 3 days on low- and high-residue diets, respectively. With each diet, daily fecal output and the number of daytime anal gas evacuations were measured. On the first study day, a second scan was acquired 4 hours after a test meal (n=6) or after 4 hours with nil ingestion (n=4). On the second study day, a scan was also acquired after a spontaneous bowel movement. Results: On the low-residue diet, daily fecal volume averaged 145 ± 15 mL; subjects passed 10.6 ± 1.6 daytime anal gas evacuations and, by the third day, non-gaseous colonic content was 479 ± 36 mL. The high-residue diet increased the three parameters to 16.5 ± 2.9 anal gas evacuations, 223 ± 19 mL fecal output, and 616 ± 55 mL non-gaseous colonic content (P<.05 vs low-residue diet for all). On the low-residue diet, non-gaseous content in the right colon had increased by 41 ± 11 mL, 4 hours after the test meal, whereas no significant change was observed after 4-hour fast (-15 ± 8 mL; P=.006 vs fed). Defecation significantly reduced the non-gaseous content in distal colonic segments. Conclusion & inferences: Colonic content exhibits physiologic variations with an approximate 1/3 daily turnover produced by meals and defecation, superimposed over diet-related day-to-day variations.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Diagnòstic per la imatge
dc.subjectÀrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica
dc.subject.lcshAbdomen-Magnetic resonance imaging
dc.subject.lcshGastrointestinal gas
dc.subject.lcshIntestines--Microbiology
dc.subject.lcshDefecation
dc.subject.othercolonic content
dc.subject.otherdiet
dc.subject.otherfecal output
dc.subject.otherintestinal gas
dc.subject.othermeals
dc.titleColonic content: effect of diet, meals, and defecation
dc.typeArticle
dc.subject.lemacAbdomen-Imatges per ressonància magnètica
dc.subject.lemacGasos gastrointestinals
dc.subject.lemacIntestins--Microbiologia
dc.subject.lemacDefecació
dc.contributor.groupUniversitat Politècnica de Catalunya. ViRVIG - Grup de Recerca en Visualització, Realitat Virtual i Interacció Gràfica
dc.identifier.doi10.1111/nmo.12930
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
drac.iddocument19768526
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorBendezú, Á., Mego, M., Monclús, E., Merino, X., Accarino, A., Malagelada, J., Navazo, I., Azpiroz, F.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameNeurogastroenterology and motility
upcommons.citation.volume29
upcommons.citation.number2


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