Biofunctionalization of patterned PLLA surfaces with RGD, REDV and YIGSR peptides to promote endothelial cells adhesion and migration
CovenanteeUniversität des Saarlandes
Document typeConference lecture
Rights accessOpen Access
Angioplasty and stent implantation open the blocked artery and restore proper blood flow after atherosclerosis disease. Despite their utility, intracoronary stents induce two types of complications: in-stent restenosis and thrombosis. Recently, biodegradable poly-L-lactic acid (PLLA) stents have been inserted to restore the healed artery, reabsorb and consequently avoid late stent thrombosis . Moreover, rapid stent endothelialisation is one of the main goals in order to heal the damaged tissue and decrease in-stent restenosis . The present work combines topographical modification and peptide functionalization of PLLA surfaces to increase endothelial cells adhesion and migration, and thus enhance endothelialization.
CitationSchieber, T.A., Mas-Moruno, C., Gil, J., Mücklich, F., Pegueroles, Marta. Biofunctionalization of patterned PLLA surfaces with RGD, REDV and YIGSR peptides to promote endothelial cells adhesion and migration. A: European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society. "European Cells and Materials". Uppsala: 2016.