Contemporary technologies as implemented in the field of healthcare have provided the everyday clinical practice with a plethora of tools to be used in various settings. In this field, distributed and networked embedded systems, such as Wireless Sensor Networks (WSNs), are the most promising technology to achieve continuous monitoring of aged people for their own safety, without affecting their daily activities. WSN4QoL is a Marie Curie project involving academic and industrial partners from three EU countries, which aims to show how new WSNsbased technologies suit the specific requirements of pervasive healthcare applications. In particular, in this paper, the WSN4QoL's system architecture is presented as designed to exploit the Network Coding (NC) mechanisms to achieve energy efficiency in the wireless communications and distributed positioning solutions to locate patients in indoor home environments. The system has been validated through experimental activities using commercial off the shelf (COTS) WSN testbeds and medical devices prototypes offered by a commercial partner. Results demonstrate that NC helps in achieving substantial gains in terms of energy efficiency as compared to traditional relay mechanisms, while the proposed positioning solution is able to locate people in indoor environments at a sub-room accuracy level, without requiring any extra dedicated hardware.