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CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactisAward-winning

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Cano Garrido, Olivia
Cespedes, Maria Virtudes
Unzueta, Ugutz
Roldan, Monica
Cubarsí Morera, RafaelMés informacióMés informació
Vazquez Gómez, Esther
García Fruitós, Elena
Villaverde Corrales, Antonio Pedro
Document typeArticle
Defense date2016-09-01
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time the ability of this platform as producer of complex, self-assembling protein materials. Materials & methods: Biophysical properties, cell penetrability and in vivo biodistribution upon systemic administration of tumor-targeted protein nanoparticles produced in L. lactis have been compared with the equivalent material produced in E. coli. Results: Protein nanoparticles have been efficiently produced in L. lactis, showing the desired size, internalization properties and biodistribution. Conclusion: In vitro and in vivo data confirm the potential and robustness of the production platform, pointing out L. lactis as a fascinating cell factory for the biofabrication of protein materials intended for therapeutic applications.
CitationCano, O., Cespedes, M., Unzueta, U., Roldan, M., Cubarsi, R., Vazquez, E., García, E., Villaverde, A. CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis. "Nanomedicine", 1 Setembre 2016, vol. 18, núm. 18, p. 2387-2398. 
Award-winningAward-winning
URIhttp://hdl.handle.net/2117/100661
DOI10.2217/nnm-2016-0200
ISSN1743-5889
Publisher versionhttp://www.futuremedicine.com/doi/10.2217/nnm-2016-0200
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  • gAGE - grup d'Astronomia i GEomàtica - Articles de revista [73]
  • Departament de Matemàtiques - Articles de revista [2.895]
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