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dc.contributor.authorEchebarría Domínguez, Blas
dc.contributor.authorÁlvarez Lacalle, Enrique
dc.contributor.authorRodríguez Cantalapiedra, Inma
dc.contributor.authorPeñaranda Ayllón, Angelina
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2017-02-02T13:52:42Z
dc.date.issued2016-02-29
dc.identifier.citationEchebarria, B., Alvarez-Lacalle, E., Rodriguez Cantalapiedra, I., Peñaranda, A. Mechanisms Underlying Electro-Mechanical Cardiac Alternans. A: "Nonlinear dynamics in biological systems". Berlín: Springer, 2016, p. 113-128.
dc.identifier.isbn978-3-319-33054-9
dc.identifier.urihttp://hdl.handle.net/2117/100492
dc.description.abstractElectro-mechanical cardiac alternans consists in beat-to-beat changes in the strength of cardiac contraction. Despite its important role in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the sarcoplasmic reticulum calcium level (SR Ca load). However, cytosolic calcium alternans observed without concurrent oscillations in the SR Ca content suggests an alternative mechanism related to a dysfunction in the dynamics of the ryanodine receptor (RyR2). In this chapter we review recent results regarding the relative role of SR Ca content fluctuations and SR refractoriness for the appearance of alternans in both ventricular and atrial cells.
dc.format.extent16 p.
dc.language.isoeng
dc.publisherSpringer
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshArrhythmia
dc.subject.otherElectro-Mechanical Cardiac Alternans
dc.titleMechanisms Underlying Electro-Mechanical Cardiac Alternans
dc.typePart of book or chapter of book
dc.subject.lemacArítmia
dc.subject.lemacElectromecànica
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
dc.contributor.groupUniversitat Politècnica de Catalunya. GICITED - Grup Interdiciplinari de Ciència i Tecnologia en l'Edificació
dc.identifier.doi10.1007/978-3-319-33054-9_6
dc.relation.publisherversionhttp://link.springer.com.recursos.biblioteca.upc.edu/book/10.1007%2F978-3-319-33054-9
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac19672960
dc.description.versionPostprint (author's final draft)
dc.date.lift10000-01-01
local.citation.authorEchebarria, B.; Alvarez-Lacalle, E.; Rodriguez Cantalapiedra, I.; Peñaranda, A.
local.citation.pubplaceBerlín
local.citation.publicationNameNonlinear dynamics in biological systems
local.citation.startingPage113
local.citation.endingPage128


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