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Collective cell durotaxis emerges from long-range intercellular force transmission
dc.contributor.author | Sunyer, Raimon |
dc.contributor.author | Conte, Vito |
dc.contributor.author | Escribano, Jorge |
dc.contributor.author | Elosegui Artola, Alberto |
dc.contributor.author | Labernadie, Anna |
dc.contributor.author | Valon, Leo |
dc.contributor.author | Navajas Navarro, Daniel |
dc.contributor.author | Garcia Aznar, José Manuel |
dc.contributor.author | Muñoz Romero, José |
dc.contributor.author | Trepat, Xavier |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Matemàtiques |
dc.date.accessioned | 2017-02-01T10:48:46Z |
dc.date.available | 2017-03-02T01:30:28Z |
dc.date.issued | 2016-09-09 |
dc.identifier.citation | Sunyer, R., Conte, Vito, Escribano, J., Elosegui, A., Labernadie, A., Valon, L., Navajas, D., Garcia, J., Muñoz, J.J., Trepat, Xavier. Collective cell durotaxis emerges from long-range intercellular force transmission. "Science", 9 Setembre 2016, vol. 353, núm. 6304, p. 1157-1161. |
dc.identifier.issn | 0036-8075 |
dc.identifier.uri | http://hdl.handle.net/2117/100437 |
dc.description.abstract | The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This emergent mode of directed collective cell migration applied to a variety of epithelial cell types, required the action of myosin motors, and originated from supracellular transmission of contractile physical forces. To explain the observed phenomenology, we developed a generalized clutch model in which local stick-slip dynamics of cell-matrix adhesions was integrated to the tissue level through cell-cell junctions. Collective durotaxis is far more efficient than single-cell durotaxis; it thus emerges as a robust mechanism to direct cell migration during development, wound healing, and collective cancer cell invasion. |
dc.format.extent | 5 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica |
dc.subject.lcsh | Cancer cells |
dc.title | Collective cell durotaxis emerges from long-range intercellular force transmission |
dc.type | Article |
dc.subject.lemac | Cèl·lules canceroses |
dc.contributor.group | Universitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria |
dc.identifier.doi | 10.1126/science.aaf7119 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://science.sciencemag.org/content/353/6304/1157 |
dc.rights.access | Open Access |
local.identifier.drac | 19331709 |
dc.description.version | Postprint (author's final draft) |
dc.relation.projectid | info:eu-repo/grantAgreement/MINECO//DPI2013-43727-R/ES/MODELOS COMPUTACIONALES PARA DINAMICA MULTICELULAR: APLICACION A EMBRIOGENESIS Y MOVILIDAD CELULAR EN TEJIDOS/ |
local.citation.author | Sunyer, R.; Conte, Vito; Escribano, J.; Elosegui, A.; Labernadie, A.; Valon, L.; Navajas, D.; Garcia, J.; Muñoz, J.J.; Trepat, Xavier |
local.citation.publicationName | Science |
local.citation.volume | 353 |
local.citation.number | 6304 |
local.citation.startingPage | 1157 |
local.citation.endingPage | 1161 |
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