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Computational modeling of acute myocardial infarction
dc.contributor.author | Sáez Viñas, Pablo |
dc.contributor.author | Kuhl, E. |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental |
dc.date.accessioned | 2017-01-25T18:46:40Z |
dc.date.available | 2017-11-01T01:30:32Z |
dc.date.issued | 2016-07 |
dc.identifier.citation | Saez, P., Kuhl, E. Computational modeling of acute myocardial infarction. "Computer methods in biomechanics and biomedical engineering", Juliol 2016, vol. 19, núm. 10, p. 1107-1115. |
dc.identifier.issn | 1025-5842 |
dc.identifier.uri | http://hdl.handle.net/2117/100078 |
dc.description | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Computer Methods in Biomechanics and Biomedical Engineering on October, 2016, available online at: http://www.tandfonline.com/10.1080/10255842.2015.1105965 |
dc.description.abstract | Myocardial infarction, commonly known as heart attack, is caused by reduced blood supply and damages the heart muscle because of a lack of oxygen. Myocardial infarction initiates a cascade of biochemical and mechanical events. In the early stages, cardiomyocytes death, wall thinning, collagen degradation, and ventricular dilation are the immediate consequences of myocardial infarction. In the later stages, collagenous scar formation in the infarcted zone and hypertrophy of the non-infarcted zone are auto-regulatory mechanisms to partly correct for these events. Here we propose a computational model for the short-term adaptation after myocardial infarction using the continuum theory of multiplicative growth. Our model captures the effects of cell death initiating wall thinning, and collagen degradation initiating ventricular dilation. Our simulations agree well with clinical observations in early myocardial infarction. They represent a first step toward simulating the progression of myocardial infarction with the ultimate goal to predict the propensity toward heart failure as a function of infarct intensity, location, and size. |
dc.format.extent | 9 p. |
dc.language.iso | eng |
dc.publisher | Gordon and Breach Science Publishers |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Mètodes numèrics |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut::Medicina |
dc.subject.lcsh | Myocardial infarction |
dc.subject.lcsh | Computer simulation |
dc.subject.other | Biomechanics |
dc.subject.other | growth |
dc.subject.other | smooth muscle cells |
dc.subject.other | hypertension |
dc.subject.other | finite element method |
dc.title | Computational modeling of acute myocardial infarction |
dc.type | Article |
dc.subject.lemac | Infart de miocardi |
dc.subject.lemac | Simulació per ordinador |
dc.contributor.group | Universitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria |
dc.identifier.doi | 10.1080/10255842.2015.1105965 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.tandfonline.com/doi/full/10.1080/10255842.2015.1105965 |
dc.rights.access | Open Access |
local.identifier.drac | 19102494 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Saez, P.; Kuhl, E. |
local.citation.publicationName | Computer methods in biomechanics and biomedical engineering |
local.citation.volume | 19 |
local.citation.number | 10 |
local.citation.startingPage | 1107 |
local.citation.endingPage | 1115 |
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