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dc.contributor.authorSáez Viñas, Pablo
dc.contributor.authorKuhl, E.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental
dc.date.accessioned2017-01-25T18:46:40Z
dc.date.available2017-11-01T01:30:32Z
dc.date.issued2016-07
dc.identifier.citationSaez, P., Kuhl, E. Computational modeling of acute myocardial infarction. "Computer methods in biomechanics and biomedical engineering", Juliol 2016, vol. 19, núm. 10, p. 1107-1115.
dc.identifier.issn1025-5842
dc.identifier.urihttp://hdl.handle.net/2117/100078
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis Group in Computer Methods in Biomechanics and Biomedical Engineering on October, 2016, available online at: http://www.tandfonline.com/10.1080/10255842.2015.1105965
dc.description.abstractMyocardial infarction, commonly known as heart attack, is caused by reduced blood supply and damages the heart muscle because of a lack of oxygen. Myocardial infarction initiates a cascade of biochemical and mechanical events. In the early stages, cardiomyocytes death, wall thinning, collagen degradation, and ventricular dilation are the immediate consequences of myocardial infarction. In the later stages, collagenous scar formation in the infarcted zone and hypertrophy of the non-infarcted zone are auto-regulatory mechanisms to partly correct for these events. Here we propose a computational model for the short-term adaptation after myocardial infarction using the continuum theory of multiplicative growth. Our model captures the effects of cell death initiating wall thinning, and collagen degradation initiating ventricular dilation. Our simulations agree well with clinical observations in early myocardial infarction. They represent a first step toward simulating the progression of myocardial infarction with the ultimate goal to predict the propensity toward heart failure as a function of infarct intensity, location, and size.
dc.format.extent9 p.
dc.language.isoeng
dc.publisherGordon and Breach Science Publishers
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Mètodes numèrics
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina
dc.subject.lcshMyocardial infarction
dc.subject.lcshComputer simulation
dc.subject.otherBiomechanics
dc.subject.other growth
dc.subject.other smooth muscle cells
dc.subject.other hypertension
dc.subject.other finite element method
dc.titleComputational modeling of acute myocardial infarction
dc.typeArticle
dc.subject.lemacInfart de miocardi
dc.subject.lemacSimulació per ordinador
dc.contributor.groupUniversitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria
dc.identifier.doi10.1080/10255842.2015.1105965
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.tandfonline.com/doi/full/10.1080/10255842.2015.1105965
dc.rights.accessOpen Access
local.identifier.drac19102494
dc.description.versionPostprint (author's final draft)
local.citation.authorSaez, P.; Kuhl, E.
local.citation.publicationNameComputer methods in biomechanics and biomedical engineering
local.citation.volume19
local.citation.number10
local.citation.startingPage1107
local.citation.endingPage1115


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