Nonlinear physics of electrical wave propagation in the heart: a review
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10.1088/0034-4885/79/9/096601
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/100011
Tipus de documentArticle
Data publicació2016-08-12
Condicions d'accésAccés obert
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Abstract
The beating of the heart is a synchronized contraction of muscle cells
(myocytes) that are triggered by a periodic sequence of electrical waves (action
potentials) originating in the sino-atrial node and propagating over the atria and
the ventricles. Cardiac arrhythmias like atrial and ventricular fibrillation (AF,VF)
or ventricular tachycardia (VT) are caused by disruptions and instabilities of these
electrical excitations, that lead to the emergence of rotating waves (VT) and turbulent
wave patterns (AF,VF). Numerous simulation and experimental studies during the
last 20 years have addressed these topics. In this review we focus on the nonlinear
dynamics of wave propagation in the heart with an emphasis on the theory of pulses,
spirals and scroll waves and their instabilities in excitable media and their application
to cardiac modeling. After an introduction into electrophysiological models for action
potential propagation, the modeling and analysis of spatiotemporal alternans, spiral
and scroll meandering, spiral breakup and scroll wave instabilities like negative line
tension and sproing are reviewed in depth and discussed with emphasis on their impact
in cardiac arrhythmias.
CitacióAlonso, S., Baer, M., Echebarria, B. Nonlinear physics of electrical wave propagation in the heart: a review. "Reports on progress in physics", 12 Agost 2016, vol. 79, núm. 9, p. 096601-096700.
ISSN0034-4885
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Alonso_Bar_Echebarria_2016_Preprint.pdf | 4,349Mb | Visualitza/Obre |