On equivalence and bioequivalence testing

Visualitza/Obre
Tipus de documentArticle
Data publicació2008
EditorInstitut d'Estadística de Catalunya
Condicions d'accésAccés obert
Abstract
Equivalence testing is the natural approach to many statistical problems. First, its main application, bioequivalence testing, is reviewed. The basic concepts of bioequivalence testing (2×2 crossover
designs, TOST, interval inclusion principle, etc.) and its problems (TOST biased character, the carryover problem, etc.) are considered. Next, equivalence testing is discussed more generally. Some applications and methods are reviewed and the relation of equivalence testing and distance-based
inference is highlighted. A new distance-based method to determine whether two gene lists are equivalent in terms of their annotations in the Gene Ontology illustrates these ideas. We end with a general discussion and some suggestions for future research.
CitacióOcaña i Rebull, Jordi [et al.]. On equivalence and bioequivalence testing. "SORT", 2008, vol. 32, núm. 2, p. 151-176.
ISSN1696-2281
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