Influence of temperature on the topological features of inner cavities in cytoglobin
Visualitza/Obre
Tipus de documentText en actes de congrés
Data publicació2015-05-05
EditorBarcelona Supercomputing Center
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Cytoglobin (Cygb) is a novel member of the globin family in man, but
there is no clear evidence about its biological function. Cygb exhibits
a highly complex ligand rebinding kinetics, which agrees with the
structural plasticity of the inner cavities and tunnels found in the
protein matrix. In this work we have examined the effect of
temperature on the topological features of Cygb. To this end, the
structural and dynamical properties of human Cygb are compared
with those determined for the Antarctic fish Chaenocephalus
aceratus. The results support a distinct temperature-dependence of
the topological features in the two proteins, suggesting different
adaptations to cold and warm environments.
CitacióSeira, Constantí; Luque, F. Javier; Bidon-Chanal, Axel. Influence of temperature on the topological features of inner cavities in cytoglobin. A: "BSC Doctoral Symposium (2nd: 2015: Barcelona)". 2nd ed. Barcelona: Barcelona Supercomputing Center, 2015, p. 134-135.
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
Influence_of_temperature_DS2105-BoAv11-10.pdf | 286,3Kb | Visualitza/Obre |