Inter-residue interactions in membrane proteins
Visualitza/Obre
Tipus de documentText en actes de congrés
Data publicació2015-05-05
EditorBarcelona Supercomputing Center
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Knowing the precise 3D-structure of a protein is crucial to
understand its functional mechanism at the molecular level and to
develop new pharmacological agents to targeting it. Nowadays only
a few hundred integral membrane protein structures have been
solved at high resolution due to the associated technical difficulties.
In the present study we aim to characterize the main interactions in
alpha and beta membrane proteins that are responsible of the
maintenance of the overall structure. With this purpose, two nonredundant
databases of alpha and beta transmembrane segments
were constructed and analysed. The interactions that stabilize the
structure of alpha and beta membrane proteins were quantified. The
results reveal important differences in inter-residues interactions
between alpha and beta membrane proteins. This novel structural
information may be useful in predicting 3D models of proteins
lacking structural information or in refining initial models of alpha
and beta membrane proteins.
CitacióMayol, Eduardo [et al.]. Inter-residue interactions in membrane proteins. A: "BSC Doctoral Symposium (2nd: 2015: Barcelona)". 2nd ed. Barcelona: Barcelona Supercomputing Center, 2015, p. 79-80.
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
Inter-residue_DS2105-BoAv11-17.pdf | 202,8Kb | Visualitza/Obre |