The City of Santos always had its development closely linked to its port vocation. From cargo to passengers, the development of foreign trade and the city and region have transformed the Port of Santos the largest in Latin America. During this period, the relationship between City and Port had many moments, not always in harmony. The urban expansion restricted the port and its activity affected the city. This detachment has limited the growth of tourist activity in Santos and region, even though the Cruise tours have included the Port of Santos in their itinerary for several decades. What is being done to improve the tourism and recover the identity of the city’s port is the objective of this article, which makes a brief historical account about the relationship between the City and Port of Santos, and its current developments.