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dc.contributor.authorRodríguez Cantalapiedra, Inma
dc.contributor.authorPeñaranda Ayllón, Angelina
dc.contributor.authorEchebarría Domínguez, Blas
dc.date.accessioned2012-02-20T10:49:05Z
dc.date.available2012-02-20T10:49:05Z
dc.date.issued2011-11-16
dc.identifier.citationRodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas. Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue. A: Jornada de Recerca i Innovació a l'Escola de Camins. "Jornada de Recerca i Innovació a l'Escola de Camins". Barcelona: Universitat Politècnica de Catalunya. Escola Tècnica Superior d'Enginyers de Camins Canals i Ports de Barcelona, 2011.
dc.identifier.urihttp://hdl.handle.net/2099/11677
dc.description.abstractPhase-2 reentry is a basic mechanism for the transition to VT and VF in the heart. It is thought to underly many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada syndrome. Reentry is usually linked to heterogeneity in tissue repolarization. We study some circumstances under which a region of depolarized tissue can reexcite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. Simulations are performed using a simplified ionic model that reproduces well the ventricular action potential (AP). We analyze first the conditions that lead to very short action potentials (APs). Then, we show that reexcitation takes place via a slow (calcium current induced) pulse that propagates into the region of short APs until it encounters excitable tissue. In two dimensions, this may give rise to reentry with the formation of counter-rotating spiral waves.
dc.format.extent4 p.
dc.language.isoeng
dc.publisherUniversitat Politècnica de Catalunya. Escola Tècnica Superior d'Enginyers de Camins Canals i Ports de Barcelona
dc.relation.ispartofJornada de Recerca i Innovació a l'Escola de Camins (2011: Barcelona)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshHeart
dc.subject.lcshVentricular fibrillation
dc.subject.lcshPulse
dc.subject.otherPhase-2 reentry
dc.titleSlow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue
dc.typeConference lecture
dc.subject.lemacCor
dc.subject.lemacFibril·lació ventricular
dc.subject.lemacPols (Fisiologia)
dc.rights.accessOpen Access
local.citation.authorRodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas
local.citation.contributorJornada de Recerca i Innovació a l'Escola de Camins
local.citation.pubplaceBarcelona
local.citation.publicationNameJornada de Recerca i Innovació a l'Escola de Camins


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