Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue

Cita com:
hdl:2099/11677
Document typeConference lecture
Defense date2011-11-16
PublisherUniversitat Politècnica de Catalunya. Escola Tècnica Superior d'Enginyers de Camins Canals i Ports de Barcelona
Rights accessOpen Access
This work is protected by the corresponding intellectual and industrial property rights.
Except where otherwise noted, its contents are licensed under a Creative Commons license
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Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Phase-2 reentry is a basic mechanism for the transition to VT and VF in the heart. It is
thought to underly many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada syndrome. Reentry is usually linked to heterogeneity in tissue
repolarization. We study some circumstances under which a region of depolarized tissue can reexcite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. Simulations are performed using a simplified ionic model that reproduces well the ventricular action potential (AP). We analyze first the conditions that lead to very short action potentials (APs). Then, we show that reexcitation takes place via a slow (calcium
current induced) pulse that propagates into the region of short APs until it encounters
excitable tissue. In two dimensions, this may give rise to reentry with the formation of counter-rotating spiral waves.
CitationRodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas. Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue. A: Jornada de Recerca i Innovació a l'Escola de Camins. "Jornada de Recerca i Innovació a l'Escola de Camins". Barcelona: Universitat Politècnica de Catalunya. Escola Tècnica Superior d'Enginyers de Camins Canals i Ports de Barcelona, 2011.
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