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dc.contributorPetrov, Dimitri
dc.contributor.authorMarro Sánchez, Mònica
dc.date.accessioned2009-10-09T10:27:45Z
dc.date.available2009-10-09T10:27:45Z
dc.date.issued2009-06-09
dc.identifier.urihttp://hdl.handle.net/2099.1/7586
dc.descriptionProjecte realitzat en col.laboració amb el centre ICFO-Institut de Ciències Fotòniques
dc.description.abstractEmodin (6-methyl-1,3,8 trihydroxyanthraquinone) is considered as a potential candidate for photodynamic therapy for the treatment of cancer. A success in using of the molecule depends among other factors on the knowledge how fast it penetrates through the cell membrane and then diffuses inside the cell. A spatial distribution of emodin inside cancerous cells is also an important factor. The aim of this study is to investigate the diffusion of emodin in cancerous cells by means of a non invasive and sensitive technique: Surface Enhanced Raman scattering which permits us to study the evolution of the small amount of emodin inside single living cells. The experimental results were compared with a theoretical model that simulated the Brownian diffusion of particles. From this comparison and comparing with previous results in fluorescence spectroscopy we have found that: for a long time, emodin is accumulated in the cytoplasm in a region close to the membrane. The result is discussed in terms of emodin being stored in cell organelles located in the cytoplasm.
dc.language.isoeng
dc.publisherUniversitat Politècnica de Catalunya
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
dc.subject.lcshRaman effect
dc.subject.lcshCancer -- Treatment
dc.subject.otherSurface Enhanced Raman scattering
dc.subject.otherBrownian diffusion
dc.subject.otherEmodin
dc.subject.otherSilver probe
dc.titleEmodin diffusion in cancerous living cells studied by means of Raman spectroscopy enhanced by plasmon effects
dc.typeMaster thesis
dc.subject.lemacRaman, Efecte de
dc.subject.lemacCàncer -- Tractament
dc.rights.accessOpen Access
dc.audience.educationlevelMàster
dc.audience.mediatorEscola Tècnica Superior d'Enginyeria Industrial de Barcelona


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain