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dc.contributorSánchez Pla, Àlex
dc.contributor.authorSerra Cayuela, Arnau
dc.date.accessioned2015-02-04T11:01:31Z
dc.date.issued2015-01
dc.identifier.urihttp://hdl.handle.net/2099.1/24942
dc.description.abstractIn the present work it is reviewed the the statistical tools available for the biomarker discovery process. Resampling techniques, feature selection, classifiers and metric to evaluate the performance of the biomarkers is reviewed. All the above concepts are tested, applying them into an appropriate work-flow, in a real prostate cancer study. The aim is to find biomarkes to be able to classify men depending the aggressiveness of the cancer after an intervention, from the analysis of the miRNA expression obtained from qPCR. Three different comparisons are assessed, and in each one a total of 20 models are compared to find the best. The R/Bioconductor CMA package is used to perform the analysis. Potential biomarkers are found, although further studies are recommended before its commercialization or other use.
dc.language.isoeng
dc.publisherUniversitat Politècnica de Catalunya
dc.publisherUniversitat de Barcelona
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica
dc.subject.lcshStatistics - Applications
dc.subject.otherProstate cancer
dc.subject.otherBiomarker
dc.subject.otherR
dc.subject.otherCMA
dc.subject.otherSupervised classification
dc.subject.otherCross-validation
dc.subject.otherMachine learning
dc.subject.otherModel building
dc.subject.otherMiRNA
dc.subject.otherRandom forest
dc.subject.otherQPCR
dc.titleBuilding and validating biomarkers. Comparison of methods and application to prostate cancer
dc.typeMaster thesis
dc.subject.lemacEstadística matemàtica--Aplicacions
dc.subject.amsClassificació AMS::62 Statistics::62P Applications
dc.identifier.slugFME-1072
dc.rights.accessRestricted access - author's decision
dc.date.lift10000-01-01
dc.date.updated2015-01-30T05:47:07Z
dc.audience.educationlevelMàster
dc.audience.mediatorUniversitat Politècnica de Catalunya. Facultat de Matemàtiques i Estadística


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