Development and evaluation of titanium content in biodegradable glass scaffolds for bone regeneration
Visualitza/Obre
Report (1,714Mb) (Accés restringit)
Estadístiques de LA Referencia / Recolecta
Inclou dades d'ús des de 2022
Cita com:
hdl:2099.1/10565
Tutor / directorEngel, Elisabeth,
Tipus de documentProjecte Final de Màster Oficial
Data2010-02
Condicions d'accésAccés restringit per decisió de l'autor
Tots els drets reservats. Aquesta obra està protegida pels drets de propietat intel·lectual i
industrial corresponents. Sense perjudici de les exempcions legals existents, queda prohibida la seva
reproducció, distribució, comunicació pública o transformació sense l'autorització del titular dels drets
Abstract
The field of Tissue Engineering has been developed in order to the replace the tissues that
are lost to disease, donor tissue rejection and due to donor tissue shortages. The main
aspect of Tissue Engineering is to avoid these problems by creating biological substitutes
that are capable of replacing the damaged tissue. Scaffold design and development is one of
the major steps of this master’s thesis.
The main aim of this thesis is to develop and characterize scaffolds for Tissue Engineering
applications. For this the strategy used is:
1. To study, prepare and characterize composite scaffolds processed by Solvent Casting and
Salt Leaching method.
2. To characterize the microstructure and surface composition of five different formulations
of Calcium Phosphate glass (CaP) P2O5–CaO–Na2O–TiO2 with 0,3,5,8 and 11 mol% of TiO2.
The characterization techniques used were Scanning Electron Microscopy-Energy Dispersive
Spectroscopy (SEM-EDS), X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC),
and Zeta Potential.
3. The degradation of different PLA-CaP glass films by selective electrode measurements.
Scaffolds and membranes are made of a composite of polylactic acid (PLA) polymer and a
calcium phosphate soluble glass. The compositions containing 50 weight% of glass particles
and 50 weight % of PLA were chosen for preparing scaffolds and membranes further
followed by characterization techniques which include degradation and surface properties.
The degradation of the scaffolds was studied for a period of 2 weeks.
SEM-EDS analysis is performed to obtain morphology information, elemental composition
information for different CaP glasses and their scaffolds.XRD analysis gave information
about the structure and phases of the CaP glasses and the glass transition temperature is
obtained with the DSC analysis.
The results obtained from the master’s thesis confirm the potential of biodegradable
materials for a wide range of applications in regenerative medicine. However only three
compositions of the total five studied gave result a bioactive glass.
MatèriesBone cements, Biomedical materials, Tissue engineering, Ciments ossis, Biomaterials, Enginyeria de teixits
TitulacióMÀSTER UNIVERSITARI ERASMUS MUNDUS EN CIÈNCIA I ENGINYERIA DE MATERIALS AVANÇATS (Pla 2014)
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
thesis new Prathap.pdf | Report | 1,714Mb | Accés restringit |