Capítols de llibrehttp://hdl.handle.net/2117/843132024-03-28T20:03:57Z2024-03-28T20:03:57ZHybrid hydrogels with stimuli-responsive properties to electric and magnetic fieldsGarcía Torres, José Manuelhttp://hdl.handle.net/2117/4049892024-03-20T09:00:22Z2024-03-20T08:51:01ZHybrid hydrogels with stimuli-responsive properties to electric and magnetic fields
García Torres, José Manuel
Hydrogels are a promising type of soft material featuring great similarity to biological tissues due to their inherent characteristics, such as high-water content, flexibility, softness, or low elastic modulus. Imparting multifunctionality to hydrogels to be triggered by external stimuli is considered to have a high potential for innovative application in the biomedical field by regulatory agencies, such as FDA and EMA. Thus, functional hybrid systems based on the combination of nanomaterials and hydrogels are a new class of materials offering new opportunities for living organ isms-machine interfacing for application in a wide variety of fields ranging from biomedical engineering to soft robotics, soft electronics, environmental or energy science. The objective of this chapter is to review the latest advances in multifunc tional hybrid hydrogels with responsiveness to electric and magnetic fields and with applications in the biomedical field.
2024-03-20T08:51:01ZGarcía Torres, José ManuelHydrogels are a promising type of soft material featuring great similarity to biological tissues due to their inherent characteristics, such as high-water content, flexibility, softness, or low elastic modulus. Imparting multifunctionality to hydrogels to be triggered by external stimuli is considered to have a high potential for innovative application in the biomedical field by regulatory agencies, such as FDA and EMA. Thus, functional hybrid systems based on the combination of nanomaterials and hydrogels are a new class of materials offering new opportunities for living organ isms-machine interfacing for application in a wide variety of fields ranging from biomedical engineering to soft robotics, soft electronics, environmental or energy science. The objective of this chapter is to review the latest advances in multifunc tional hybrid hydrogels with responsiveness to electric and magnetic fields and with applications in the biomedical field.Biomedical applications of powder metallurgyRodríguez Contreras, Alejandra MaríaPunset Fuste, MiquelManero Planella, José MaríaCALERO, JOSE ANTONIOTorres Garrido, Diegohttp://hdl.handle.net/2117/3627162022-02-21T15:50:33Z2022-02-21T15:49:49ZBiomedical applications of powder metallurgy
Rodríguez Contreras, Alejandra María; Punset Fuste, Miquel; Manero Planella, José María; CALERO, JOSE ANTONIO; Torres Garrido, Diego
The performance and properties of Titanium (Ti) and its alloys can be fully exploited for biomedical applications such as orthopedic and dental implants, when porous structures are used. Such Ti structures can matched the bone mechanical properties, providing a solution to the stress-shielding effect problem and facilitating implant biointegration. Powder metallurgy (PM) combined with space holder (SH) technology is an appealing process to produce porous implants. This article briefly discusses the suitability of the PM with SH technology to produce porous structures from the perspectives of both design and manufacture for the production of medical devices.
2022-02-21T15:49:49ZRodríguez Contreras, Alejandra MaríaPunset Fuste, MiquelManero Planella, José MaríaCALERO, JOSE ANTONIOTorres Garrido, DiegoThe performance and properties of Titanium (Ti) and its alloys can be fully exploited for biomedical applications such as orthopedic and dental implants, when porous structures are used. Such Ti structures can matched the bone mechanical properties, providing a solution to the stress-shielding effect problem and facilitating implant biointegration. Powder metallurgy (PM) combined with space holder (SH) technology is an appealing process to produce porous implants. This article briefly discusses the suitability of the PM with SH technology to produce porous structures from the perspectives of both design and manufacture for the production of medical devices.Surface functionalization of biomaterials for bone tissue regeneration and repairMas Moruno, Carloshttp://hdl.handle.net/2117/1149732020-07-23T21:32:23Z2018-03-09T09:37:17ZSurface functionalization of biomaterials for bone tissue regeneration and repair
Mas Moruno, Carlos
Biomaterials have evolved from mere bioinert substrates, required only to passively support cell adhesion and growth, to bioactive cell-instructive surfaces with the capacity to tune cell behavior and dictate cell differentiation. Biofunctionalization stands out as a versatile approach to address such ambitious goal. This strategy relies on the use of cell signaling biomolecules derived from the extracellular matrix and aims to mimic the microenvironment of cell-matrix interactions to harness cell behavior and guide tissue regeneration.
In the field of bone tissue engineering, surface functionalization has classically been addressed by using proteins and peptides from the extracellular matrix of bone. However, both approaches are not exempt from limitations, and newer strategies have been proposed as promising alternatives to achieve optimal levels of bone growth and the successful osseointegration of implantable biomaterials. In this regard, integrin selective peptidomimetics and multifunctional systems constitute a new paradigm in surface functionalization. This work will review these strategies, with special emphasis in the concept of multifunctionality.
2018-03-09T09:37:17ZMas Moruno, CarlosBiomaterials have evolved from mere bioinert substrates, required only to passively support cell adhesion and growth, to bioactive cell-instructive surfaces with the capacity to tune cell behavior and dictate cell differentiation. Biofunctionalization stands out as a versatile approach to address such ambitious goal. This strategy relies on the use of cell signaling biomolecules derived from the extracellular matrix and aims to mimic the microenvironment of cell-matrix interactions to harness cell behavior and guide tissue regeneration.
In the field of bone tissue engineering, surface functionalization has classically been addressed by using proteins and peptides from the extracellular matrix of bone. However, both approaches are not exempt from limitations, and newer strategies have been proposed as promising alternatives to achieve optimal levels of bone growth and the successful osseointegration of implantable biomaterials. In this regard, integrin selective peptidomimetics and multifunctional systems constitute a new paradigm in surface functionalization. This work will review these strategies, with special emphasis in the concept of multifunctionality.Dental Implants: Plasma polymerization for antibacterial coatingsBuxadera Palomero, JuditCanal Barnils, CristinaGil Mur, Francisco JavierRodríguez Rius, Danielhttp://hdl.handle.net/2117/1012952021-04-01T03:43:26Z2017-02-21T11:07:11ZDental Implants: Plasma polymerization for antibacterial coatings
Buxadera Palomero, Judit; Canal Barnils, Cristina; Gil Mur, Francisco Javier; Rodríguez Rius, Daniel
Dental implants are widely used to overcome tooth loss. The material of choice for this application is titanium, due to its excellent mechanical properties, high corrosion resistance, and high biocompatibility. Despite the high success rate of titanium dental implants, there are a significant number of failures due to the infection of the surrounding tissues. The best way to avoid infections related to the use of dental implants is to achieve an antibacterial surface, either by physical or chemical modification of the titanium surface or by coating the implant with a polymer. These surfaces are intended to avoid the initial adhesion of bacteria, thus avoiding biofilm formation. This entry summarizes the main strategies to impart antibacterial character to the surface of the titanium implants, focusing on the strategies using plasma polymerization as a deposition technique to coat the titanium surface.
2017-02-21T11:07:11ZBuxadera Palomero, JuditCanal Barnils, CristinaGil Mur, Francisco JavierRodríguez Rius, DanielDental implants are widely used to overcome tooth loss. The material of choice for this application is titanium, due to its excellent mechanical properties, high corrosion resistance, and high biocompatibility. Despite the high success rate of titanium dental implants, there are a significant number of failures due to the infection of the surrounding tissues. The best way to avoid infections related to the use of dental implants is to achieve an antibacterial surface, either by physical or chemical modification of the titanium surface or by coating the implant with a polymer. These surfaces are intended to avoid the initial adhesion of bacteria, thus avoiding biofilm formation. This entry summarizes the main strategies to impart antibacterial character to the surface of the titanium implants, focusing on the strategies using plasma polymerization as a deposition technique to coat the titanium surface.New PHB-producing Bacillus Strain from Environmental SamplesRodríguez Contreras, Alejandra MaríaMarqués Calvo, M. Soledadhttp://hdl.handle.net/2117/843122020-11-11T05:12:54Z2016-03-14T14:04:16ZNew PHB-producing Bacillus Strain from Environmental Samples
Rodríguez Contreras, Alejandra María; Marqués Calvo, M. Soledad
Many microorganisms are known to synthesize poly[(R)-3-hydroxybutyrate] (PHB) from renewable resources. This biocompatible and biodegradable biopolyester possesses similar properties to some of the conventional plastics such as polypropylene. However, PHB is not competitive with the polymers from the oil industry so far due to its high production costs. An aproach to overcome this problem is to discover new microorganisms with higher polymer productivity. Therefore, the main objectives of this chapter are focused on finding a new PHB-producing bacterium from environmental samples capable of growing in different salts conditions, and on characterizing the biopolymer produced. A bacterial isolation process was carried out with environmental samples of water and mud from different Bolivian salt lakes. One bacterium from the Uyuni salt lake fulfilled the selection conditions and was consequently used in an initial fermentation to generate biopolymer in order to identify and characterize it via Fourier transform infrared microscopy (FTIR), nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC) and differential scanning calorimetry (DS) analyses. Then, the microorganism was tested in different fed-batch fermentation processes to determine its PHB production potential, and to analyse the influence of salt content in the medium on both, the cell growth and the PHB production. The selected biopolymer synthetised in a conventional medium used for industrial biopolymer production was identified as PHB homopolymer. Surprisingly, it featured several fractions of different molecular masses and thermal properties unusual for PHB. The results of fermentation in the 3L-bioreactor showed a high specific growth rate. The highest polymer content ever reached for the genus Bacillus was up to 70% PHB of cell dry mass. The strain turned out to be appealing not only due to its growth and PHB accumulation kinetics under the cultivation conditions investigated, but also due to the thermal properties of the PHB produced. Also, the strain shows a high adaptability to media with high salt concentrations, constantly synthesizing PHB. The strain was taxonomically identified by molecular processes as the novel strain of Bacillus megaterium uyuni S29. It is deposited in the Spanish Type Culture Collection and its nucleotide sequence is deposited at GenBank. The tolerance to the salt, together with the production of biopolymer, makes this strain viable for its utilization in the biotechnological production of PHA as well as for other applications such as the treatment of salty wastewater.
2016-03-14T14:04:16ZRodríguez Contreras, Alejandra MaríaMarqués Calvo, M. SoledadMany microorganisms are known to synthesize poly[(R)-3-hydroxybutyrate] (PHB) from renewable resources. This biocompatible and biodegradable biopolyester possesses similar properties to some of the conventional plastics such as polypropylene. However, PHB is not competitive with the polymers from the oil industry so far due to its high production costs. An aproach to overcome this problem is to discover new microorganisms with higher polymer productivity. Therefore, the main objectives of this chapter are focused on finding a new PHB-producing bacterium from environmental samples capable of growing in different salts conditions, and on characterizing the biopolymer produced. A bacterial isolation process was carried out with environmental samples of water and mud from different Bolivian salt lakes. One bacterium from the Uyuni salt lake fulfilled the selection conditions and was consequently used in an initial fermentation to generate biopolymer in order to identify and characterize it via Fourier transform infrared microscopy (FTIR), nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC) and differential scanning calorimetry (DS) analyses. Then, the microorganism was tested in different fed-batch fermentation processes to determine its PHB production potential, and to analyse the influence of salt content in the medium on both, the cell growth and the PHB production. The selected biopolymer synthetised in a conventional medium used for industrial biopolymer production was identified as PHB homopolymer. Surprisingly, it featured several fractions of different molecular masses and thermal properties unusual for PHB. The results of fermentation in the 3L-bioreactor showed a high specific growth rate. The highest polymer content ever reached for the genus Bacillus was up to 70% PHB of cell dry mass. The strain turned out to be appealing not only due to its growth and PHB accumulation kinetics under the cultivation conditions investigated, but also due to the thermal properties of the PHB produced. Also, the strain shows a high adaptability to media with high salt concentrations, constantly synthesizing PHB. The strain was taxonomically identified by molecular processes as the novel strain of Bacillus megaterium uyuni S29. It is deposited in the Spanish Type Culture Collection and its nucleotide sequence is deposited at GenBank. The tolerance to the salt, together with the production of biopolymer, makes this strain viable for its utilization in the biotechnological production of PHA as well as for other applications such as the treatment of salty wastewater.